This Event is licensed under the Creative Commons BY-SA license. This license allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use. If you remix, adapt, or build upon the material, you must license the modified material under identical terms.
Event: 179
Key Event Title
A descriptive phrase which defines a discrete biological change that can be measured.
More help
Decreased, Mitochondrial fatty acid beta-oxidation
Short name
The KE short name should be a reasonable abbreviation of the KE title and is used in labelling this object throughout the AOP-Wiki.
More help
Decreased, Mitochondrial fatty acid beta-oxidation
Explore in a Third Party Tool
Exploration Options for Key Events
Click links below to explore KE 179, Decreased, Mitochondrial fatty acid beta-oxidation in tools offered by third parties.
A description of the biological state being observed or measured, the biological compartment in which it is measured, and its general role in the biology should be provided.
More help
Fatty acid oxidation in liver tissue is controlled by PPARalpha signaling networks (Evans et al 2004). The PPARalpha signaling network controls expression of the genes within metabolic pathways that catalyze fatty acid oxidation reactions (Desvergne and Wahli 1999).
In the context of the EMOD/M2AOP prototyping, there are 2 components to the How it is Measured or Detected field, a structured component for adding Assay information and a free text component for unstructured descriptive information.In the free text field, include a description of the type(s) of measurements that can be employed to evaluate the KE and the relative level of scientific confidence in those measurements. These can range from citation of specific validated test guidelines, citation of specific methods published in the peer reviewed literature, or outlines of a general protocol or approach (e.g., a protein may be measured by ELISA). Do not provide detailed protocols.
More help
A variety of approaches establishing the effects of PPARalpha signaling on fatty acid oxidation are reviewed in Evans et al (2004).
Observed meausures are instances of assay results that support this Key Event
More help
| ID | Experimental Effect | Biological Object | Biological Process | Method of Measurement | Notes | Evidence Source ID | Citation (first author, year) |
|---|
Observed meausures are instances of assay results that support this Key Event
More help
| ID | Stressor | Sample (short_name) | Assay | Effect |
|---|
The KE, as defined by a set structured ontology terms consisting of a biological process, object, and action with each term originating from one of 14 biological ontologies (Ives, et al., 2017; https://aopwiki.org/info_pages/2/info_linked_pages/7#List). Biological process describes dynamics of the underlying biological system (e.g., receptor signalling).Biological process describes dynamics of the underlying biological system (e.g., receptor signaling). The biological object is the subject of the perturbation (e.g., a specific biological receptor that is activated or inhibited). Action represents the direction of perturbation of this system (generally increased or decreased; e.g., ‘decreased’ in the case of a receptor that is inhibited to indicate a decrease in the signaling by that receptor). Note that when editing Event Components, clicking an existing Event Component from the Suggestions menu will autopopulate these fields, along with their source ID and description. To clear any fields before submitting the event component, use the 'Clear process,' 'Clear object,' or 'Clear action' buttons. If a desired term does not exist, a new term request may be made via Term Requests. Event components may not be edited; to edit an event component, remove the existing event component and create a new one using the terms that you wish to add. Further information on Event Components and Biological Context may be viewed on the attached pdf.
More help
| Process | Object | Action |
|---|---|---|
| fatty acid beta-oxidation | fatty acid | decreased |
Structured terms, selected from a drop-down menu, are used to identify the level of biological organization for each KE.
More help
| Level of Biological Organization |
|---|
| Molecular |
Cell term
The location/biological environment in which the event takes place.The biological context describes the location/biological environment in which the event takes place. For molecular/cellular events this would include the cellular context (if known), organ context, and species/life stage/sex for which the event is relevant. For tissue/organ events cellular context is not applicable. For individual/population events, the organ context is not applicable. Further information on Event Components and Biological Context may be viewed on the attached pdf.
More help
| Cell term |
|---|
| hepatocyte |
Organ term
The location/biological environment in which the event takes place.The biological context describes the location/biological environment in which the event takes place. For molecular/cellular events this would include the cellular context (if known), organ context, and species/life stage/sex for which the event is relevant. For tissue/organ events cellular context is not applicable. For individual/population events, the organ context is not applicable. Further information on Event Components and Biological Context may be viewed on the attached pdf.
More help
AOPs Including This Key Event
All of the AOPs that are linked to this KE will automatically be listed in this subsection. This table can be particularly useful for derivation of AOP networks including the KE.Clicking on the name of the AOP will bring you to the individual page for that AOP.
More help
| AOP Name | Role of event in AOP | Point of Contact | Author Status | OECD Status |
|---|---|---|---|---|
| Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis | KeyEvent | Evgeniia Kazymova (send email) | Under Development: Contributions and Comments Welcome | |
| PXR activation to steatosis | KeyEvent | Cataia Ives (send email) | Under Development: Contributions and Comments Welcome | |
| ERa inactivation leads to insulin resistance in skeletal muscle and metabolic syndrome | KeyEvent | Agnes Aggy (send email) | Under development: Not open for comment. Do not cite |
Taxonomic Applicability
Latin or common names of a species or broader taxonomic grouping (e.g., class, order, family) that help to define the biological applicability domain of the KE.In many cases, individual species identified in these structured fields will be those for which the strongest evidence used in constructing the AOP was available in relation to this KE.
More help
| Term | Scientific Term | Evidence | Link |
|---|---|---|---|
| Homo sapiens | Homo sapiens | High | NCBI |
Life Stages
An indication of the the relevant life stage(s) for this KE.
More help
Sex Applicability
An indication of the the relevant sex for this KE.
More help
A description of the scientific basis for the indicated domains of applicability and the WoE calls (if provided).
More help
See review for Human PPARalpha signaling in (Evans et al 2004).
List of the literature that was cited for this KE description.
More help
Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocrine Reviews 20(5): 649-688.
Evans RM, Barish GD, Wang YX: PPARs and the complex journey to obesity. Nat Med 2004, 10(4):355-361.