Study Design details for SD# 8
Reference Details
| Title | Authors | Year | DOI |
|---|---|---|---|
| Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7 | Meganathan K, Prakasam R, Baldridge D, Gontarz P, Zhang B, Urano F, Bonni A, Maloney SE, Turner TN, Huettner JE, Constantino JN, Kroll KL. | 2021 | https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-021-01080-7 |
Study Type: in vitro
Regimen description
Human iPSCs cultured with rat primaty cortical astrocytes cultured for 15 days + 3 weeks. Whole cell currents and mebrane potentails were recorded after stimualation to choline and acetycholine.
Subject Properties
| Taxon Term | Strain | Sex | Life Stage |
|---|---|---|---|
| human and other cells in culture | cExNPCs and cINPCs (human iPSCs) rat primary cortical astrocytes (strain not specified) | Unspecific | Development |
Observations
| ID | Stressor | Sample (short_name) | Assay | Effect | Associated Key Events | |
|---|---|---|---|---|---|---|
| 8 | 15: , pluripotent stem cell, brain, Development | Voltage clamp recording | functional change |