Study Design details for SD# 10
Reference Details
| Title | Authors | Year | DOI |
|---|---|---|---|
| ToxCast bioactivity data for Resmethrin | US EPA, Tox21 | accessed 2024-04-01 | https://comptox.epa.gov/dashboard/chemical/invitrodb/DTXSID7022253 |
Study Type: in vitro
Regimen description
Data from the assay component NVS_ADME_hCYP19A1 was analyzed into 1 assay endpoint. This assay endpoint, NVS_ADME_hCYP19A1, was analyzed in the positive analysis fitting direction relative to Acetonitrile as the negative control and baseline of activity. Using a type of enzyme reporter, loss-of-signal activity can be used to understand changes in the enzymatic activity as they relate to the gene CYP19A1. Furthermore, this assay endpoint can be referred to as a primary readout, because this assay has produced multiple assay endpoints where this one serves a enzymatic activity function. To generalize the intended target to other relatable targets, this assay endpoint is annotated to the cyp intended target family, where the subfamily is steroidogenesis-related.
Subject Properties
| Taxon Term | Strain | Sex | Life Stage |
|---|---|---|---|
| Homo sapiens | n/a | Unspecific | Not Otherwise Specified |
Observations
| ID | Stressor | Sample (short_name) | Assay | Effect | Associated Key Events | |
|---|---|---|---|---|---|---|
| 10 | NVS_ADME_hCYP19A1 (ToxCast Assay Endpoint Aeid 319) | decreased | ||||
| 11 | NVS_ADME_hCYP19A1 (ToxCast Assay Endpoint Aeid 319) | decreased |
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| 12 | 17: 0.5 h, Not Otherwise Specified |
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