Status epilepticus leads to Increased, glutamate

Sustained seizure activity that lasts longer than 5 minutes, or repetitive seizures without regaining consciousness constitute status epilepticus (Lowenstein and Alldredge, 1998). Release of glutamate through this sustained seizure activity follows that of KER 1890: Occurrence, Focal Seizure leading to Increased, glutamate.

For AChE inhibition-induced status epilepticus, there are in total three points that differentiate the key events of focal seizure onset (KE 1623) and status epilepticus in the AChE inhibition-induced model of seizure activity: (i) Focal seizures are localized seizures that have not spread/undergone secondary generalization (Kandel et al., 2013). (ii) Status epilepticus has specifically defined requirements that must be met for a subject to be considered to be in status epilepticus, those being that the seizure(s) must have lasted for at least 5 minutes or there are repetitive seizures occurring without the subject regaining function and consciousness (Lowenstein and Alldredge, 1998). The transition between focal seizure activity and generalized status epilepticus occurs somewhere between 5 and 40 minutes after seizure onset (McDonough and Shih, 1997) (iii) The treatment options available for attenuating seizure activity induced by AChE inhibition are best when the seizures initially begin as a focal seizure and reduced when the subject has been in the state of status epilepticus for a prolonged period of time. Specifically, in the early phases of the pathology after exposure to the AChE inhibitor, a cholinergic phase is present, and effective treatment options include both regular anti-seizure treatment and anticholinergic therapy to prevent the seizures from continuing, whereas in the later phase of the pathology, where the seizure activity is now glutamatergically driven, anticholinergic therapy is no longer effective, and the seizure activity can only be effectively treated with the usual therapies (McDonough and Shih, 1997).

The papers in Table 1 from the Quantitative Understanding section of KER 1890, Occurrence, Focal Seizure leading to Increased, glutamate  present electroencephalogram (EEG) data from timepoint 0 and onward after local injection of seizure-inducing compounds. The full spectrum of the EEG is not published, and one would need to contact the author as needed.  No additional data found specific to status epilepticus and the release of glutamate.

See KER 1890: Occurrence, Focal Seizure leading to Increased, glutamate.