{"id":99,"title":"Histamine (H2) receptor antagonism leading to reduced survival","short_name":"H2 block to reduced survival","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:49.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":638,"event":"Antagonism, Histamine Receptor (H2)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":633,"event":"Decrease, histaminergic neuron excitation","event_type":"KeyEvent"},{"event_id":634,"event":"N/A, sedation","event_type":"KeyEvent"},{"event_id":635,"event":"Decreased, locomotion","event_type":"KeyEvent"},{"event_id":341,"event":"Impairment, Learning and memory","event_type":"KeyEvent"}],"aop_aos":[{"event_id":636,"event":"Decreased, survival","event_type":"AdverseOutcome"},{"event_id":588,"event":"Increased, predation","event_type":"AdverseOutcome"}],"relationships":[{"relation":316,"upstream_event_id":633,"upstream_event":"Decrease, histaminergic neuron excitation","downstream_event_id":634,"downstream_event":"N/A, sedation"},{"relation":317,"upstream_event_id":634,"upstream_event":"N/A, sedation","downstream_event_id":635,"downstream_event":"Decreased, locomotion"},{"relation":318,"upstream_event_id":635,"upstream_event":"Decreased, locomotion","downstream_event_id":588,"downstream_event":"Increased, predation"},{"relation":321,"upstream_event_id":588,"upstream_event":"Increased, predation","downstream_event_id":636,"downstream_event":"Decreased, survival"},{"relation":725,"upstream_event_id":638,"upstream_event":"Antagonism, Histamine Receptor (H2)","downstream_event_id":633,"downstream_event":"Decrease, histaminergic neuron excitation"},{"relation":1512,"upstream_event_id":633,"upstream_event":"Decrease, histaminergic neuron excitation","downstream_event_id":341,"downstream_event":"Impairment, Learning and memory"},{"relation":1513,"upstream_event_id":341,"upstream_event":"Impairment, Learning and memory","downstream_event_id":635,"downstream_event":"Decreased, locomotion"}]}