Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)

54739-18-3

CJOFXWAVKWHTFT-XSFVSMFZSA-N

Fluvoxamine

1-Pentanone, 5-methoxy-1-[4-(trifluoromethyl)phenyl]-, O-(2-aminoethyl)oxime, (1E)-

DTXSID2044002

PR:000015189

PR sodium-dependent serotonin transporter

GO:0098810

GO neurotransmitter reuptake

GO:0051610

GO serotonin uptake

GO:0001820

GO serotonin secretion

NBO:0000018

NBO fear/anxiety related behavior

MP:0014039

MP abnormal sheltering behavior

GO:0002120

GO predatory behavior

WIKI decreased

WIKI increased

Fluoxetine

2016-11-29T18:42:27

Fluvoxamine

2016-11-29T18:42:27

WCS_90988

common ecological species Pimephales promelas

52640

NCBI Echinogammarus marinus

Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)

Molecular

Inhibitors of the serotonin reuptake transporter (SERT; 5-hydroxytryptamine transporter; 5-HTT) block the reuptake of the neurotransmitter serotonin, increasing its residence time in synapses.

Toxcast assays that target the serotonin transporter (5-HTT; SERT) gene SLC6A4 include: NVS_TR_rSERT,NVS_TR_rSERT.

CL:0000100

CL motor neuron

AOPWiki 2016-11-29T18:41:25

2017-09-16T10:15:51

Increased, serotonin (5-HT)

Cellular

Increased concentration of serotonin in neuronal junctions either due to increased release of serotonin or diminished reuptake.

CL:0000100

CL motor neuron

AOPWiki 2016-11-29T18:41:25

2017-09-16T10:15:52

Decreased, anxiety

Individual

AOPWiki 2016-11-29T18:41:25

2016-12-03T16:37:50

Decreased, sheltering

Individual

AOPWiki 2016-11-29T18:41:25

2016-12-03T16:37:50

Increased, predation

Population

AOPWiki 2016-11-29T18:41:25

2016-12-03T16:37:50

<upstream-id>b9b12ba6-db49-43f5-b33b-eca15aaf85c7</upstream-id> <downstream-id>764b3b08-4ce8-4ef0-9136-8136901ea838</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a0ebae08> AOPWiki 2016-11-29T18:41:34

2016-12-03T16:37:58

<upstream-id>764b3b08-4ce8-4ef0-9136-8136901ea838</upstream-id> <downstream-id>86abf3f2-a7ae-41aa-8bf8-73c7b03419b8</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a1038050> AOPWiki 2016-11-29T18:41:34

2016-12-03T16:37:58

<upstream-id>0e2f92d8-7fac-460b-bc88-b930ce58d300</upstream-id> <downstream-id>b9b12ba6-db49-43f5-b33b-eca15aaf85c7</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a1232d60> AOPWiki 2016-11-29T18:41:34

2016-12-03T16:37:58

<upstream-id>86abf3f2-a7ae-41aa-8bf8-73c7b03419b8</upstream-id> <downstream-id>8f7fe355-18b3-46cc-a036-1966cef7fee0</downstream-id>

#<Reference::ActiveRecord_Associations_CollectionProxy:0x00005eb8a1710580> AOPWiki 2016-11-29T18:41:34

2016-12-03T16:37:59

5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation

5-HTT block to incr. predation

Allie Always

Bryan Brooks, Baylor University, USA Kellie Fay, US EPA Ksenia Groh, EAWAG, Switzerland

BY-SA

1.29

1.0

adjacent

Not Specified

Not Specified non-adjacent

Not Specified

Not Specified non-adjacent

Not Specified

Not Specified non-adjacent

Not Specified

Not Specified Not Specified

This putative AOP is based on a few studies in fish and mollusks and should be considered preliminary only.

AOPWiki 2016-11-29T18:41:16

2023-09-25T16:26:49