{"id":80,"title":"Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure","short_name":"nAChR activation - colony loss 4","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:48.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":559,"event":"Activation, Nicotinic acetylcholine receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":177,"event":"N/A, Mitochondrial dysfunction 1","event_type":"KeyEvent"},{"event_id":570,"event":"Accumulation, Damaged mitochondrial DNA","event_type":"KeyEvent"},{"event_id":571,"event":"Accelerated, Aging","event_type":"KeyEvent"},{"event_id":664,"event":"Overwhelmed, Mitochondrial DNA repair mechanisms","event_type":"KeyEvent"}],"aop_aos":[{"event_id":572,"event":"Decrease, Number of worker bees","event_type":"AdverseOutcome"},{"event_id":568,"event":"impaired, Hive thermoregulation","event_type":"AdverseOutcome"},{"event_id":563,"event":"Death/Failure, Colony","event_type":"AdverseOutcome"}],"relationships":[{"relation":332,"upstream_event_id":559,"upstream_event":"Activation, Nicotinic acetylcholine receptor","downstream_event_id":177,"downstream_event":"N/A, Mitochondrial dysfunction 1"},{"relation":333,"upstream_event_id":177,"upstream_event":"N/A, Mitochondrial dysfunction 1","downstream_event_id":664,"downstream_event":"Overwhelmed, Mitochondrial DNA repair mechanisms"},{"relation":334,"upstream_event_id":664,"upstream_event":"Overwhelmed, Mitochondrial DNA repair mechanisms","downstream_event_id":570,"downstream_event":"Accumulation, Damaged mitochondrial DNA"},{"relation":335,"upstream_event_id":570,"upstream_event":"Accumulation, Damaged mitochondrial DNA","downstream_event_id":571,"downstream_event":"Accelerated, Aging"},{"relation":336,"upstream_event_id":571,"upstream_event":"Accelerated, Aging","downstream_event_id":572,"downstream_event":"Decrease, Number of worker bees"},{"relation":337,"upstream_event_id":572,"upstream_event":"Decrease, Number of worker bees","downstream_event_id":568,"downstream_event":"impaired, Hive thermoregulation"},{"relation":338,"upstream_event_id":568,"upstream_event":"impaired, Hive thermoregulation","downstream_event_id":563,"downstream_event":"Death/Failure, Colony"}]}