{"id":78,"title":"Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1","short_name":"nAChR activation - colony death/failure2","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:48.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":559,"event":"Activation, Nicotinic acetylcholine receptor","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":177,"event":"N/A, Mitochondrial dysfunction 1","event_type":"KeyEvent"},{"event_id":386,"event":"Decrease of neuronal network function","event_type":"KeyEvent"},{"event_id":341,"event":"Impairment, Learning and memory","event_type":"KeyEvent"},{"event_id":564,"event":"Abnormal, Roll change within caste","event_type":"KeyEvent"},{"event_id":565,"event":"Reduced, Brood care","event_type":"KeyEvent"}],"aop_aos":[{"event_id":566,"event":"impaired, Larval development","event_type":"AdverseOutcome"},{"event_id":563,"event":"Death/Failure, Colony","event_type":"AdverseOutcome"}],"relationships":[{"relation":342,"upstream_event_id":559,"upstream_event":"Activation, Nicotinic acetylcholine receptor","downstream_event_id":177,"downstream_event":"N/A, Mitochondrial dysfunction 1"},{"relation":343,"upstream_event_id":177,"upstream_event":"N/A, Mitochondrial dysfunction 1","downstream_event_id":386,"downstream_event":"Decrease of neuronal network function"},{"relation":344,"upstream_event_id":386,"upstream_event":"Decrease of neuronal network function","downstream_event_id":341,"downstream_event":"Impairment, Learning and memory"},{"relation":345,"upstream_event_id":341,"upstream_event":"Impairment, Learning and memory","downstream_event_id":564,"downstream_event":"Abnormal, Roll change within caste"},{"relation":346,"upstream_event_id":564,"upstream_event":"Abnormal, Roll change within caste","downstream_event_id":565,"downstream_event":"Reduced, Brood care"},{"relation":347,"upstream_event_id":565,"upstream_event":"Reduced, Brood care","downstream_event_id":566,"downstream_event":"impaired, Larval development"},{"relation":348,"upstream_event_id":566,"upstream_event":"impaired, Larval development","downstream_event_id":563,"downstream_event":"Death/Failure, Colony"}]}