D005298 MESH fertility CL:0000019 CL sperm PR:000011405 PR COUP transcription factor 2 GO:0044026 GO DNA hypermethylation GO:0035624 GO receptor transactivation MP:0013603 MP abnormal fetal Leydig cell differentiation HP:0008715 HP Testicular dysgenesis MP:0013604 MP abnormal adult Leydig cell differentiation 2 WIKI decreased 1 WIKI increased 10116 NCBI Rattus norvegicus Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult test Individual AOPWiki 2016-11-29T18:41:25 2016-12-03T16:37:50 Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis Molecular AOPWiki 2016-11-29T18:41:26 2016-12-03T16:37:51 Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells Cellular AOPWiki 2016-11-29T18:41:26 2016-12-03T16:37:51 Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells Organ AOPWiki 2016-11-29T18:41:25 2016-12-03T16:37:50 Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells Cellular AOPWiki 2016-11-29T18:41:25 2016-12-03T16:37:50 Hypermethylation & Leydig Cells Arthur Author <p>Gary Klinefelter</p> BY-SA 1.29 1.0 High Male High Foetal Moderate Adult, reproductively mature High AOPWiki 2016-11-29T18:41:16 2023-09-25T16:26:48