{"id":74,"title":"Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis","short_name":"Hypermethylation \u0026 Leydig Cells","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:48.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":662,"event":"Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":655,"event":"Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells","event_type":"KeyEvent"},{"event_id":540,"event":"Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells","event_type":"KeyEvent"},{"event_id":541,"event":"Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":543,"event":"Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis","event_type":"AdverseOutcome"}],"relationships":[]}