{"id":67,"title":"Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis","short_name":"Decreased Fetal Testosterone 2","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:47.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":658,"event":"Decreased testosterone by the fetal Leydig cells, Increased estradiol","event_type":"MolecularInitiatingEvent"},{"event_id":659,"event":"Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":655,"event":"Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells","event_type":"KeyEvent"},{"event_id":660,"event":"decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells","event_type":"KeyEvent"},{"event_id":656,"event":"Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":505,"event":"Decreased sperm quantity / quality in the adult, Decreased fertility ","event_type":"AdverseOutcome"}],"relationships":[]}