Decreased sperm quantity / quality in the adult, Decreased fertility

D005298

MESH fertility

CL:0000019

CL sperm

CHEBI:16827

CHEBI corticosterone

PR:000011406

PR glucocorticoid receptor

PR:000011405

PR COUP transcription factor 2

GO:0004883

GO glucocorticoid receptor activity

GO:0035624

GO receptor transactivation

MP:0013604

MP abnormal adult Leydig cell differentiation

MP:0013603

MP abnormal fetal Leydig cell differentiation

HP:0008715

HP Testicular dysgenesis

WIKI decreased

WIKI increased

10116

NCBI Rattus norvegicus

Decreased sperm quantity / quality in the adult, Decreased fertility

Individual

AOPWiki 2016-11-29T18:41:25

2016-12-03T16:37:50

Decreased testosterone by the fetal Leydig cells, Increased corticosterone

Cellular

CL:0000178

CL Leydig cell

AOPWiki 2016-11-29T18:41:26

2017-09-16T10:15:26

Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists

Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid recept

Cellular

AOPWiki 2016-11-29T18:41:26

2016-12-03T16:37:51

Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells

Cellular

AOPWiki 2016-11-29T18:41:26

2016-12-03T16:37:51

Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells

Cellular

AOPWiki 2016-11-29T18:41:26

2016-12-03T16:37:51

Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells

Organ

AOPWiki 2016-11-29T18:41:26

2016-12-03T16:37:51

Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis

Decreased Fetal Testosterone 1

Cataia Ives

<p>Gary Klinefelter and Susan Laws</p>

BY-SA

1.29

1.0

High Male

High

Foetal

Moderate

Adult, reproductively mature

High

AOPWiki 2016-11-29T18:41:16

2023-09-25T16:26:47