{"id":65,"title":"XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals","short_name":"NIS and Neurodevelopment","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:47.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":424,"event":"Inhibition, Na+/I- symporter (NIS)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":280,"event":"Thyroxine (T4) in neuronal tissue, Decreased ","event_type":"KeyEvent"},{"event_id":186,"event":"Altered, Neuroanatomy","event_type":"KeyEvent"},{"event_id":192,"event":"Altered, Neurophysiology","event_type":"KeyEvent"}],"aop_aos":[{"event_id":402,"event":"Cognitive Function, Decreased ","event_type":"AdverseOutcome"}],"relationships":[{"relation":246,"upstream_event_id":424,"upstream_event":"Inhibition, Na+/I- symporter (NIS)","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":247,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":248,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":280,"downstream_event":"Thyroxine (T4) in neuronal tissue, Decreased "},{"relation":249,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":402,"downstream_event":"Cognitive Function, Decreased "},{"relation":250,"upstream_event_id":186,"upstream_event":"Altered, Neuroanatomy","downstream_event_id":192,"downstream_event":"Altered, Neurophysiology"},{"relation":251,"upstream_event_id":192,"upstream_event":"Altered, Neurophysiology","downstream_event_id":402,"downstream_event":"Cognitive Function, Decreased "}]}