{"id":64,"title":"Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility","short_name":"Adult Leydig Cell Dysfunction","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:47.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":494,"event":"Glucocorticoid Receptor Agonist, Activation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":495,"event":"Repressed expression of steroidogenic enzymes ","event_type":"KeyEvent"},{"event_id":496,"event":"Increased apoptosis, decreased fetal/adult Leydig Cells ","event_type":"KeyEvent"},{"event_id":413,"event":"Reduction, Testosterone synthesis in Leydig cells","event_type":"KeyEvent"},{"event_id":446,"event":"Reduction, fetal/adult testosterone ","event_type":"KeyEvent"},{"event_id":520,"event":"Decreased sperm quantity or quality in the adult, Decreased fertility ","event_type":"KeyEvent"}],"aop_aos":[{"event_id":406,"event":"impaired, Fertility","event_type":"AdverseOutcome"}],"relationships":[{"relation":1514,"upstream_event_id":494,"upstream_event":"Glucocorticoid Receptor Agonist, Activation","downstream_event_id":496,"downstream_event":"Increased apoptosis, decreased fetal/adult Leydig Cells "},{"relation":1515,"upstream_event_id":494,"upstream_event":"Glucocorticoid Receptor Agonist, Activation","downstream_event_id":495,"downstream_event":"Repressed expression of steroidogenic enzymes "},{"relation":1516,"upstream_event_id":496,"upstream_event":"Increased apoptosis, decreased fetal/adult Leydig Cells ","downstream_event_id":413,"downstream_event":"Reduction, Testosterone synthesis in Leydig cells"},{"relation":1517,"upstream_event_id":495,"upstream_event":"Repressed expression of steroidogenic enzymes ","downstream_event_id":413,"downstream_event":"Reduction, Testosterone synthesis in Leydig cells"},{"relation":1518,"upstream_event_id":413,"upstream_event":"Reduction, Testosterone synthesis in Leydig cells","downstream_event_id":446,"downstream_event":"Reduction, fetal/adult testosterone "},{"relation":1519,"upstream_event_id":446,"upstream_event":"Reduction, fetal/adult testosterone ","downstream_event_id":520,"downstream_event":"Decreased sperm quantity or quality in the adult, Decreased fertility "},{"relation":1520,"upstream_event_id":520,"upstream_event":"Decreased sperm quantity or quality in the adult, Decreased fertility ","downstream_event_id":406,"downstream_event":"impaired, Fertility"}]}