{"id":6,"title":"Antagonist binding to PPARα leading to body-weight loss","short_name":"PPARα antagonism leading to body-weight loss","created_at":"2016-11-29T18:41:15.000-05:00","updated_at":"2023-09-25T16:26:43.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":151,"stressor_name":"GW6471"},{"stressor_id":237,"stressor_name":"Nitrotoluenes (hypothesized binding)"},{"stressor_id":300,"stressor_name":"PPARalpha antagonists"}],"aop_mies":[{"event_id":998,"event":"Binding of antagonist, PPAR alpha","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1000,"event":"stabilization, PPAR alpha co-repressor","event_type":"KeyEvent"},{"event_id":858,"event":"Decreased, PPARalpha transactivation of gene expression","event_type":"KeyEvent"},{"event_id":1528,"event":"Fatty Acid Beta Oxidation, Decreased","event_type":"KeyEvent"},{"event_id":861,"event":"Decreased, Ketogenesis (production of ketone bodies)","event_type":"KeyEvent"},{"event_id":862,"event":"Not Increased, Circulating Ketone Bodies","event_type":"KeyEvent"},{"event_id":863,"event":"Increased, Catabolism of Muscle Protein","event_type":"KeyEvent"}],"aop_aos":[{"event_id":864,"event":"Decreased, Body Weight","event_type":"AdverseOutcome"}],"relationships":[{"relation":3367,"upstream_event_id":998,"upstream_event":"Binding of antagonist, PPAR alpha","downstream_event_id":1000,"downstream_event":"stabilization, PPAR alpha co-repressor"},{"relation":665,"upstream_event_id":1000,"upstream_event":"stabilization, PPAR alpha co-repressor","downstream_event_id":858,"downstream_event":"Decreased, PPARalpha transactivation of gene expression"},{"relation":1647,"upstream_event_id":858,"upstream_event":"Decreased, PPARalpha transactivation of gene expression","downstream_event_id":1528,"downstream_event":"Fatty Acid Beta Oxidation, Decreased"},{"relation":570,"upstream_event_id":858,"upstream_event":"Decreased, PPARalpha transactivation of gene expression","downstream_event_id":861,"downstream_event":"Decreased, Ketogenesis (production of ketone bodies)"},{"relation":1648,"upstream_event_id":1528,"upstream_event":"Fatty Acid Beta Oxidation, Decreased","downstream_event_id":861,"downstream_event":"Decreased, Ketogenesis (production of ketone bodies)"},{"relation":573,"upstream_event_id":861,"upstream_event":"Decreased, Ketogenesis (production of ketone bodies)","downstream_event_id":862,"downstream_event":"Not Increased, Circulating Ketone Bodies"},{"relation":3368,"upstream_event_id":862,"upstream_event":"Not Increased, Circulating Ketone Bodies","downstream_event_id":863,"downstream_event":"Increased, Catabolism of Muscle Protein"},{"relation":575,"upstream_event_id":863,"upstream_event":"Increased, Catabolism of Muscle Protein","downstream_event_id":864,"downstream_event":"Decreased, Body Weight"}]}