{"id":51,"title":"PPARα activation leading to impaired fertility in adult male rodents ","short_name":"PPAR and reproductive toxicity","created_at":"2016-11-29T18:41:16.000-05:00","updated_at":"2023-09-25T16:26:47.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":227,"event":"Activation, PPARα","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":414,"event":"Increase, Luteinizing hormone (LH) ","event_type":"KeyEvent"},{"event_id":415,"event":"Hyperplasia, Leydig cell","event_type":"KeyEvent"},{"event_id":416,"event":"Increase proliferation, Leydig cell ","event_type":"KeyEvent"},{"event_id":446,"event":"Reduction, fetal/adult testosterone ","event_type":"KeyEvent"},{"event_id":413,"event":"Reduction, Testosterone synthesis in Leydig cells","event_type":"KeyEvent"},{"event_id":447,"event":"Reduction, Cholesterol transport in mitochondria","event_type":"KeyEvent"}],"aop_aos":[{"event_id":406,"event":"impaired, Fertility","event_type":"AdverseOutcome"}],"relationships":[{"relation":129,"upstream_event_id":416,"upstream_event":"Increase proliferation, Leydig cell ","downstream_event_id":415,"downstream_event":"Hyperplasia, Leydig cell"},{"relation":166,"upstream_event_id":413,"upstream_event":"Reduction, Testosterone synthesis in Leydig cells","downstream_event_id":446,"downstream_event":"Reduction, fetal/adult testosterone "},{"relation":167,"upstream_event_id":447,"upstream_event":"Reduction, Cholesterol transport in mitochondria","downstream_event_id":413,"downstream_event":"Reduction, Testosterone synthesis in Leydig cells"},{"relation":168,"upstream_event_id":446,"upstream_event":"Reduction, fetal/adult testosterone ","downstream_event_id":414,"downstream_event":"Increase, Luteinizing hormone (LH) "},{"relation":169,"upstream_event_id":414,"upstream_event":"Increase, Luteinizing hormone (LH) ","downstream_event_id":416,"downstream_event":"Increase proliferation, Leydig cell "},{"relation":170,"upstream_event_id":415,"upstream_event":"Hyperplasia, Leydig cell","downstream_event_id":406,"downstream_event":"impaired, Fertility"}]}