{"id":499,"title":"Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release","short_name":"MEK-ERK1/2 activation leading to deficits in learning and cognition","created_at":"2023-06-20T16:18:02.000-04:00","updated_at":"2023-09-25T16:27:14.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":59,"stressor_name":"Lead"},{"stressor_id":635,"stressor_name":"Arsenic"},{"stressor_id":335,"stressor_name":"Cadmium"},{"stressor_id":721,"stressor_name":"Manganese"},{"stressor_id":675,"stressor_name":"Heavy metals (cadmium, lead, copper, iron, nickel)"}],"aop_mies":[{"event_id":2146,"event":"Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1339,"event":"Increase, intracellular calcium","event_type":"KeyEvent"},{"event_id":2151,"event":"Disruption, neurotransmitter release","event_type":"KeyEvent"}],"aop_aos":[{"event_id":341,"event":"Impairment, Learning and memory","event_type":"AdverseOutcome"}],"relationships":[{"relation":3492,"upstream_event_id":2146,"upstream_event":"Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2","downstream_event_id":1339,"downstream_event":"Increase, intracellular calcium"},{"relation":3507,"upstream_event_id":1339,"upstream_event":"Increase, intracellular calcium","downstream_event_id":2151,"downstream_event":"Disruption, neurotransmitter release"},{"relation":3508,"upstream_event_id":2151,"upstream_event":"Disruption, neurotransmitter release","downstream_event_id":341,"downstream_event":"Impairment, Learning and memory"}]}