{"id":496,"title":"Androgen receptor agonism leading to reproduction dysfunction （in zebrafish）","short_name":"Androgen receptor agonism leading to reproduction dysfunction","created_at":"2023-05-16T21:08:20.000-04:00","updated_at":"2023-09-25T16:27:14.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":5,"stressor_name":"17beta-Trenbolone"}],"aop_mies":[{"event_id":25,"event":"Agonism, Androgen receptor","event_type":"MolecularInitiatingEvent"},{"event_id":2143,"event":"Increased, gene expression of AR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2137,"event":"Increase, Gonadotropins concentration in plasma","event_type":"KeyEvent"},{"event_id":2138,"event":"Reduction,Testosterone concentration in plasma","event_type":"KeyEvent"},{"event_id":219,"event":"Reduction, Plasma 17beta-estradiol concentrations","event_type":"KeyEvent"},{"event_id":2139,"event":"Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma ","event_type":"KeyEvent"},{"event_id":221,"event":"Reduction, Plasma vitellogenin concentrations","event_type":"KeyEvent"},{"event_id":309,"event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","event_type":"KeyEvent"},{"event_id":78,"event":"Reduction, Cumulative fecundity and spawning","event_type":"KeyEvent"}],"aop_aos":[{"event_id":442,"event":"Decreased, Population trajectory","event_type":"AdverseOutcome"}],"relationships":[{"relation":3462,"upstream_event_id":25,"upstream_event":"Agonism, Androgen receptor","downstream_event_id":2143,"downstream_event":"Increased, gene expression of AR"},{"relation":3471,"upstream_event_id":2138,"upstream_event":"Reduction,Testosterone concentration in plasma","downstream_event_id":2139,"downstream_event":"Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma "},{"relation":3463,"upstream_event_id":2143,"upstream_event":"Increased, gene expression of AR","downstream_event_id":2137,"downstream_event":"Increase, Gonadotropins concentration in plasma"},{"relation":3473,"upstream_event_id":219,"upstream_event":"Reduction, Plasma 17beta-estradiol concentrations","downstream_event_id":221,"downstream_event":"Reduction, Plasma vitellogenin concentrations"},{"relation":3464,"upstream_event_id":2137,"upstream_event":"Increase, Gonadotropins concentration in plasma","downstream_event_id":2138,"downstream_event":"Reduction,Testosterone concentration in plasma"},{"relation":3474,"upstream_event_id":25,"upstream_event":"Agonism, Androgen receptor","downstream_event_id":2139,"downstream_event":"Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma "},{"relation":3465,"upstream_event_id":2138,"upstream_event":"Reduction,Testosterone concentration in plasma","downstream_event_id":219,"downstream_event":"Reduction, Plasma 17beta-estradiol concentrations"},{"relation":3466,"upstream_event_id":219,"upstream_event":"Reduction, Plasma 17beta-estradiol concentrations","downstream_event_id":2139,"downstream_event":"Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma "},{"relation":3467,"upstream_event_id":2139,"upstream_event":"Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma ","downstream_event_id":221,"downstream_event":"Reduction, Plasma vitellogenin concentrations"},{"relation":3468,"upstream_event_id":221,"upstream_event":"Reduction, Plasma vitellogenin concentrations","downstream_event_id":309,"downstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development"},{"relation":3469,"upstream_event_id":309,"upstream_event":"Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development","downstream_event_id":78,"downstream_event":"Reduction, Cumulative fecundity and spawning"},{"relation":3470,"upstream_event_id":78,"upstream_event":"Reduction, Cumulative fecundity and spawning","downstream_event_id":442,"downstream_event":"Decreased, Population trajectory"}]}