{"id":473,"title":"Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin","short_name":"Energy deposition from Ra226 decay lowers oxygen binding capacity of hemocyanin","created_at":"2022-11-15T16:21:55.000-05:00","updated_at":"2023-09-25T16:27:13.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1686,"event":"Deposition of Energy","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1632,"event":"Increase in reactive oxygen and nitrogen species (RONS)","event_type":"KeyEvent"},{"event_id":2073,"event":"increase oxidation of the di-copper moiety of the hemocyanin active site ","event_type":"KeyEvent"},{"event_id":2074,"event":"Decreased, oxygen binding capacity by hemocyanin","event_type":"KeyEvent"},{"event_id":2075,"event":"Cognitive, sensed as hypoxic/low oxygen environment","event_type":"KeyEvent"},{"event_id":2076,"event":"Increase, hemocyanin mRNA","event_type":"KeyEvent"},{"event_id":2077,"event":"Increase, pulmonate breathing","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1521,"event":"Decrease, Growth","event_type":"AdverseOutcome"},{"event_id":1141,"event":"Decreased, Reproductive Success","event_type":"AdverseOutcome"}],"relationships":[{"relation":3273,"upstream_event_id":1686,"upstream_event":"Deposition of Energy","downstream_event_id":1632,"downstream_event":"Increase in reactive oxygen and nitrogen species (RONS)"},{"relation":3274,"upstream_event_id":1632,"upstream_event":"Increase in reactive oxygen and nitrogen species (RONS)","downstream_event_id":2073,"downstream_event":"increase oxidation of the di-copper moiety of the hemocyanin active site "},{"relation":3275,"upstream_event_id":2073,"upstream_event":"increase oxidation of the di-copper moiety of the hemocyanin active site ","downstream_event_id":2074,"downstream_event":"Decreased, oxygen binding capacity by hemocyanin"},{"relation":3276,"upstream_event_id":2073,"upstream_event":"increase oxidation of the di-copper moiety of the hemocyanin active site ","downstream_event_id":2075,"downstream_event":"Cognitive, sensed as hypoxic/low oxygen environment"},{"relation":3277,"upstream_event_id":2075,"upstream_event":"Cognitive, sensed as hypoxic/low oxygen environment","downstream_event_id":2077,"downstream_event":"Increase, pulmonate breathing"},{"relation":3278,"upstream_event_id":2077,"upstream_event":"Increase, pulmonate breathing","downstream_event_id":1521,"downstream_event":"Decrease, Growth"},{"relation":3279,"upstream_event_id":2074,"upstream_event":"Decreased, oxygen binding capacity by hemocyanin","downstream_event_id":2076,"downstream_event":"Increase, hemocyanin mRNA"},{"relation":3280,"upstream_event_id":1521,"upstream_event":"Decrease, Growth","downstream_event_id":1141,"downstream_event":"Decreased, Reproductive Success"}]}