{"id":468,"title":"Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)","short_name":"Cytopathic SARS-CoV-2 leads to hyperinflammation","created_at":"2022-09-01T03:39:14.000-04:00","updated_at":"2023-09-25T16:27:12.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1738,"event":"SARS-CoV-2 cell entry ","event_type":"KeyEvent"},{"event_id":1901,"event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","event_type":"KeyEvent"},{"event_id":1847,"event":"Increased SARS-CoV-2 production","event_type":"KeyEvent"},{"event_id":1825,"event":"Increase, Cell death","event_type":"KeyEvent"},{"event_id":1496,"event":"Increased, secretion of proinflammatory mediators","event_type":"KeyEvent"},{"event_id":1497,"event":"Increased, recruitment of inflammatory cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1868,"event":"Hyperinflammation","event_type":"AdverseOutcome"}],"relationships":[{"relation":3217,"upstream_event_id":1739,"upstream_event":"Binding to ACE2","downstream_event_id":1738,"downstream_event":"SARS-CoV-2 cell entry "},{"relation":3224,"upstream_event_id":1497,"upstream_event":"Increased, recruitment of inflammatory cells","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":3218,"upstream_event_id":1738,"upstream_event":"SARS-CoV-2 cell entry ","downstream_event_id":1901,"downstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2"},{"relation":3219,"upstream_event_id":1901,"upstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","downstream_event_id":1847,"downstream_event":"Increased SARS-CoV-2 production"},{"relation":3220,"upstream_event_id":1847,"upstream_event":"Increased SARS-CoV-2 production","downstream_event_id":1825,"downstream_event":"Increase, Cell death"},{"relation":3221,"upstream_event_id":1825,"upstream_event":"Increase, Cell death","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":3222,"upstream_event_id":1496,"upstream_event":"Increased, secretion of proinflammatory mediators","downstream_event_id":1497,"downstream_event":"Increased, recruitment of inflammatory cells"},{"relation":3223,"upstream_event_id":1497,"upstream_event":"Increased, recruitment of inflammatory cells","downstream_event_id":1868,"downstream_event":"Hyperinflammation"}]}