{"id":457,"title":"Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine","short_name":"Succinate dehydrogenase inhibition leading to increased insulin resistance","created_at":"2022-06-30T09:47:52.000-04:00","updated_at":"2023-09-25T16:27:12.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":65,"stressor_name":"Di(2-ethylhexyl) phthalate"},{"stressor_id":64,"stressor_name":"Mono(2-ethylhexyl) phthalate"}],"aop_mies":[{"event_id":2118,"event":"Succinate dehydrogenase, inhibited","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2120,"event":"Superoxide generation, increased","event_type":"KeyEvent"},{"event_id":1969,"event":"Increase, Oxidative Stress","event_type":"KeyEvent"},{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":2119,"event":"Insulin resistance, increased","event_type":"AdverseOutcome"}],"relationships":[{"relation":3390,"upstream_event_id":2118,"upstream_event":"Succinate dehydrogenase, inhibited","downstream_event_id":2120,"downstream_event":"Superoxide generation, increased"},{"relation":3429,"upstream_event_id":2120,"upstream_event":"Superoxide generation, increased","downstream_event_id":1969,"downstream_event":"Increase, Oxidative Stress"},{"relation":3430,"upstream_event_id":1969,"upstream_event":"Increase, Oxidative Stress","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":3431,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":3389,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":2119,"downstream_event":"Insulin resistance, increased"}]}