{"id":456,"title":"Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity","short_name":"Ahr mediated early stage mortality via cardiovascular toxicity","created_at":"2022-06-28T14:54:26.000-04:00","updated_at":"2023-09-25T16:27:12.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":249,"stressor_name":"2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)"}],"aop_mies":[{"event_id":18,"event":"Activation, AhR","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":944,"event":"dimerization, AHR/ARNT","event_type":"KeyEvent"},{"event_id":2021,"event":"Increase, slincR expression","event_type":"KeyEvent"},{"event_id":2020,"event":"Decrease, sox9 expression","event_type":"KeyEvent"},{"event_id":317,"event":"Altered, Cardiovascular development/function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":947,"event":"Increase, Early Life Stage Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":3135,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":944,"downstream_event":"dimerization, AHR/ARNT"},{"relation":3181,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":2020,"downstream_event":"Decrease, sox9 expression"},{"relation":3136,"upstream_event_id":944,"upstream_event":"dimerization, AHR/ARNT","downstream_event_id":2021,"downstream_event":"Increase, slincR expression"},{"relation":3182,"upstream_event_id":2021,"upstream_event":"Increase, slincR expression","downstream_event_id":317,"downstream_event":"Altered, Cardiovascular development/function"},{"relation":3137,"upstream_event_id":2021,"upstream_event":"Increase, slincR expression","downstream_event_id":2020,"downstream_event":"Decrease, sox9 expression"},{"relation":3226,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"},{"relation":3138,"upstream_event_id":2020,"upstream_event":"Decrease, sox9 expression","downstream_event_id":317,"downstream_event":"Altered, Cardiovascular development/function"},{"relation":3232,"upstream_event_id":18,"upstream_event":"Activation, AhR","downstream_event_id":317,"downstream_event":"Altered, Cardiovascular development/function"},{"relation":3139,"upstream_event_id":317,"upstream_event":"Altered, Cardiovascular development/function","downstream_event_id":947,"downstream_event":"Increase, Early Life Stage Mortality"}]}