{"id":433,"title":"hERG channel blockade leading to sudden cardiac death","short_name":"From hERG blockade to death","created_at":"2021-12-13T04:40:00.000-05:00","updated_at":"2023-09-25T16:27:10.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":2099,"event":"hERG channel blockade","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":2100,"event":"Inhibition of rapid delayed rectifying potassium current ","event_type":"KeyEvent"},{"event_id":1961,"event":"Prolongation of Action Potential Duration","event_type":"KeyEvent"},{"event_id":1962,"event":"Prolongation of QT interval","event_type":"KeyEvent"},{"event_id":1963,"event":"Torsades de Pointes","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1964,"event":"Sudden cardiac death","event_type":"AdverseOutcome"}],"relationships":[{"relation":3358,"upstream_event_id":2099,"upstream_event":"hERG channel blockade","downstream_event_id":2100,"downstream_event":"Inhibition of rapid delayed rectifying potassium current "},{"relation":3359,"upstream_event_id":2100,"upstream_event":"Inhibition of rapid delayed rectifying potassium current ","downstream_event_id":1961,"downstream_event":"Prolongation of Action Potential Duration"},{"relation":3360,"upstream_event_id":1961,"upstream_event":"Prolongation of Action Potential Duration","downstream_event_id":1962,"downstream_event":"Prolongation of QT interval"},{"relation":3364,"upstream_event_id":1962,"upstream_event":"Prolongation of QT interval","downstream_event_id":1963,"downstream_event":"Torsades de Pointes"},{"relation":3365,"upstream_event_id":1963,"upstream_event":"Torsades de Pointes","downstream_event_id":1964,"downstream_event":"Sudden cardiac death"}]}