{"id":432,"title":"Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia","short_name":"Ionizing Radiation-Induced AML","created_at":"2021-12-02T10:13:33.000-05:00","updated_at":"2023-09-25T16:27:10.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":451,"stressor_name":"Ionizing Radiation"}],"aop_mies":[{"event_id":1686,"event":"Deposition of Energy","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1632,"event":"Increase in reactive oxygen and nitrogen species (RONS)","event_type":"KeyEvent"},{"event_id":1194,"event":"Increase, DNA damage","event_type":"KeyEvent"},{"event_id":155,"event":"Inadequate DNA repair","event_type":"KeyEvent"},{"event_id":876,"event":"Increase, Mutations in Critical Genes","event_type":"KeyEvent"},{"event_id":870,"event":"Increase, Cell Proliferation","event_type":"KeyEvent"},{"event_id":1493,"event":"Increased Pro-inflammatory mediators","event_type":"KeyEvent"},{"event_id":403,"event":"Suppression, Immune system","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1955,"event":"Acute Myeloid Leukemia","event_type":"AdverseOutcome"}],"relationships":[]}