{"id":431,"title":"Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)","short_name":"Increased TNF leading to GDM","created_at":"2021-11-18T20:27:15.000-05:00","updated_at":"2023-09-25T16:27:10.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":698,"stressor_name":"Diethylhexyl phthalate"}],"aop_mies":[{"event_id":1950,"event":"Increase, TNF","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1949,"event":"Decrease, GLUT4","event_type":"KeyEvent"},{"event_id":1951,"event":"Decrease, Glucose uptake","event_type":"KeyEvent"},{"event_id":1952,"event":"Abnormal, Glucose homeostasis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1953,"event":"Gestational diabetes mellitus","event_type":"AdverseOutcome"}],"relationships":[{"relation":2893,"upstream_event_id":1950,"upstream_event":"Increase, TNF","downstream_event_id":1949,"downstream_event":"Decrease, GLUT4"},{"relation":2894,"upstream_event_id":1949,"upstream_event":"Decrease, GLUT4","downstream_event_id":1951,"downstream_event":"Decrease, Glucose uptake"},{"relation":2895,"upstream_event_id":1951,"upstream_event":"Decrease, Glucose uptake","downstream_event_id":1952,"downstream_event":"Abnormal, Glucose homeostasis"},{"relation":2896,"upstream_event_id":1952,"upstream_event":"Abnormal, Glucose homeostasis","downstream_event_id":1953,"downstream_event":"Gestational diabetes mellitus"}]}