{"id":430,"title":"Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation","short_name":"SARS-CoV-2 leads to infection proliferation","created_at":"2021-10-24T16:58:05.000-04:00","updated_at":"2023-09-25T16:27:10.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":526,"stressor_name":"SARS-CoV"},{"stressor_id":624,"stressor_name":"Sars-CoV-2"},{"stressor_id":620,"stressor_name":"HCoV-NL63"}],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1738,"event":"SARS-CoV-2 cell entry ","event_type":"KeyEvent"},{"event_id":1901,"event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","event_type":"KeyEvent"},{"event_id":1847,"event":"Increased SARS-CoV-2 production","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1939,"event":"Viral infection and host-to-host transmission, proliferated","event_type":"AdverseOutcome"}],"relationships":[{"relation":2876,"upstream_event_id":1739,"upstream_event":"Binding to ACE2","downstream_event_id":1738,"downstream_event":"SARS-CoV-2 cell entry "},{"relation":2877,"upstream_event_id":1738,"upstream_event":"SARS-CoV-2 cell entry ","downstream_event_id":1901,"downstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2"},{"relation":2878,"upstream_event_id":1901,"upstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","downstream_event_id":1847,"downstream_event":"Increased SARS-CoV-2 production"},{"relation":2879,"upstream_event_id":1847,"upstream_event":"Increased SARS-CoV-2 production","downstream_event_id":1939,"downstream_event":"Viral infection and host-to-host transmission, proliferated"}]}