{"id":427,"title":"ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.","short_name":"Downregulation of ACE2 causes multi-factorial heart injury and heart failure.","created_at":"2021-10-15T13:54:54.000-04:00","updated_at":"2023-09-25T16:27:10.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1787,"event":"Downregulation, ACE2","event_type":"KeyEvent"},{"event_id":1935,"event":"Angiotensin (1-7) levels diminished","event_type":"KeyEvent"},{"event_id":1936,"event":"Angiotensin II degradation reduced","event_type":"KeyEvent"},{"event_id":1741,"event":"Induced, Angiotensin (Ang) II accumulation","event_type":"KeyEvent"},{"event_id":1853,"event":"Hyperactivation of ACE/Ang-II/AT1R axis","event_type":"KeyEvent"},{"event_id":1937,"event":"ADAM17 expression induction","event_type":"KeyEvent"},{"event_id":1938,"event":"ACE2 increased shedding","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1535,"event":"Heart failure ","event_type":"AdverseOutcome"}],"relationships":[]}