{"id":426,"title":"SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. ","short_name":"Pericytes possess a key role in the heart injury by COVID-19.","created_at":"2021-10-15T12:13:06.000-04:00","updated_at":"2023-09-25T16:27:10.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1535,"event":"Heart failure ","event_type":"KeyEvent"},{"event_id":1738,"event":"SARS-CoV-2 cell entry ","event_type":"KeyEvent"},{"event_id":1750,"event":"Increased inflammatory immune responses","event_type":"KeyEvent"},{"event_id":1913,"event":"Endothelial cell dysfunction ","event_type":"KeyEvent"},{"event_id":1666,"event":"Induced, dysfunction of microcirculation","event_type":"KeyEvent"},{"event_id":1946,"event":"Impaired mechanotransduction of pericytes","event_type":"KeyEvent"},{"event_id":1947,"event":"Pericyte dysfunction","event_type":"KeyEvent"},{"event_id":1948,"event":"Increased ACE2 expression","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1934,"event":"Myocardial Infarction","event_type":"AdverseOutcome"}],"relationships":[]}