{"id":424,"title":"Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction","short_name":"Ox stress-mediated CFTR/ASL/CBF/MCC impairment","created_at":"2021-09-27T09:08:13.000-04:00","updated_at":"2023-09-25T16:27:09.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":319,"stressor_name":"Acrolein"},{"stressor_id":655,"stressor_name":"Ozone"},{"stressor_id":645,"stressor_name":"Cigarette smoke"}],"aop_mies":[{"event_id":1392,"event":"Oxidative Stress ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1906,"event":"Cystic Fibrosis Transmembrane Regulator Function, Decreased","event_type":"KeyEvent"},{"event_id":1907,"event":"Airway Surface Liquid Height, Decreased ","event_type":"KeyEvent"},{"event_id":1908,"event":"Cilia Beat Frequency, Decreased","event_type":"KeyEvent"},{"event_id":1909,"event":"Mucociliary Clearance, Decreased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1250,"event":"Decrease, Lung function","event_type":"AdverseOutcome"}],"relationships":[{"relation":2840,"upstream_event_id":1392,"upstream_event":"Oxidative Stress ","downstream_event_id":1906,"downstream_event":"Cystic Fibrosis Transmembrane Regulator Function, Decreased"},{"relation":2841,"upstream_event_id":1906,"upstream_event":"Cystic Fibrosis Transmembrane Regulator Function, Decreased","downstream_event_id":1907,"downstream_event":"Airway Surface Liquid Height, Decreased "},{"relation":2842,"upstream_event_id":1907,"upstream_event":"Airway Surface Liquid Height, Decreased ","downstream_event_id":1908,"downstream_event":"Cilia Beat Frequency, Decreased"},{"relation":2843,"upstream_event_id":1908,"upstream_event":"Cilia Beat Frequency, Decreased","downstream_event_id":1909,"downstream_event":"Mucociliary Clearance, Decreased"},{"relation":2844,"upstream_event_id":1909,"upstream_event":"Mucociliary Clearance, Decreased","downstream_event_id":1250,"downstream_event":"Decrease, Lung function"}]}