{"id":410,"title":"GSK3beta inactivation leading to increased mortality via defects in developing inner ear","short_name":"GSK3beta inactivation leads to increased mortality","created_at":"2021-07-14T13:47:28.000-04:00","updated_at":"2023-09-25T16:27:08.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":474,"stressor_name":"BIO (6-bromoindirubin-3’-oxime) "}],"aop_mies":[{"event_id":1647,"event":"GSK3beta inactivation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1902,"event":"Repression of Gbx2 expression","event_type":"KeyEvent"},{"event_id":1903,"event":"foxi1 expression, increased","event_type":"KeyEvent"},{"event_id":1904,"event":"six1b expression, increased","event_type":"KeyEvent"},{"event_id":1905,"event":"eya1 expression, inhibited","event_type":"KeyEvent"},{"event_id":1825,"event":"Increase, Cell death","event_type":"KeyEvent"},{"event_id":1930,"event":"altered, inner ear development","event_type":"KeyEvent"},{"event_id":1008,"event":"Reduced, Hearing","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2852,"upstream_event_id":1647,"upstream_event":"GSK3beta inactivation","downstream_event_id":1902,"downstream_event":"Repression of Gbx2 expression"},{"relation":2853,"upstream_event_id":1902,"upstream_event":"Repression of Gbx2 expression","downstream_event_id":1903,"downstream_event":"foxi1 expression, increased"},{"relation":2765,"upstream_event_id":1903,"upstream_event":"foxi1 expression, increased","downstream_event_id":1904,"downstream_event":"six1b expression, increased"},{"relation":2766,"upstream_event_id":1904,"upstream_event":"six1b expression, increased","downstream_event_id":1905,"downstream_event":"eya1 expression, inhibited"},{"relation":2767,"upstream_event_id":1905,"upstream_event":"eya1 expression, inhibited","downstream_event_id":1825,"downstream_event":"Increase, Cell death"},{"relation":2798,"upstream_event_id":1825,"upstream_event":"Increase, Cell death","downstream_event_id":1930,"downstream_event":"altered, inner ear development"},{"relation":2799,"upstream_event_id":1930,"upstream_event":"altered, inner ear development","downstream_event_id":1008,"downstream_event":"Reduced, Hearing"},{"relation":2854,"upstream_event_id":1008,"upstream_event":"Reduced, Hearing","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":2891,"upstream_event_id":351,"upstream_event":"Increased Mortality","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}