{"id":406,"title":"SARS-CoV-2 infection leading to hyperinflammation","short_name":"SARS-CoV2 to hyperinflammation","created_at":"2021-06-25T05:13:14.000-04:00","updated_at":"2023-09-25T16:27:08.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1738,"event":"SARS-CoV-2 cell entry ","event_type":"KeyEvent"},{"event_id":1847,"event":"Increased SARS-CoV-2 production","event_type":"KeyEvent"},{"event_id":1869,"event":"Diminished protective oxidative stress response","event_type":"KeyEvent"},{"event_id":1895,"event":"NLRP3 inflammasome activity, increased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1868,"event":"Hyperinflammation","event_type":"AdverseOutcome"}],"relationships":[{"relation":2720,"upstream_event_id":1739,"upstream_event":"Binding to ACE2","downstream_event_id":1738,"downstream_event":"SARS-CoV-2 cell entry "},{"relation":2721,"upstream_event_id":1738,"upstream_event":"SARS-CoV-2 cell entry ","downstream_event_id":1847,"downstream_event":"Increased SARS-CoV-2 production"},{"relation":2722,"upstream_event_id":1847,"upstream_event":"Increased SARS-CoV-2 production","downstream_event_id":1869,"downstream_event":"Diminished protective oxidative stress response"},{"relation":2723,"upstream_event_id":1869,"upstream_event":"Diminished protective oxidative stress response","downstream_event_id":1895,"downstream_event":"NLRP3 inflammasome activity, increased"},{"relation":2725,"upstream_event_id":1895,"upstream_event":"NLRP3 inflammasome activity, increased","downstream_event_id":1868,"downstream_event":"Hyperinflammation"}]}