{"id":398,"title":"Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary","short_name":"Inhibition of ALDH1A leading to reduced fertility","created_at":"2021-05-24T11:29:40.000-04:00","updated_at":"2023-09-25T16:27:07.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1880,"event":"Inhibition of ALDH1A (RALDH)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1881,"event":"Decreased, all-trans retinoic acid (atRA) concentration","event_type":"KeyEvent"},{"event_id":1882,"event":"Disrupted meiotic initiation of fetal oogonia of the ovary","event_type":"KeyEvent"},{"event_id":1883,"event":"Reduced size of the ovarian follicle pool ","event_type":"KeyEvent"},{"event_id":405,"event":"irregularities, ovarian cycle","event_type":"KeyEvent"}],"aop_aos":[{"event_id":406,"event":"impaired, Fertility","event_type":"AdverseOutcome"}],"relationships":[{"relation":2698,"upstream_event_id":1880,"upstream_event":"Inhibition of ALDH1A (RALDH)","downstream_event_id":1881,"downstream_event":"Decreased, all-trans retinoic acid (atRA) concentration"},{"relation":2817,"upstream_event_id":1881,"upstream_event":"Decreased, all-trans retinoic acid (atRA) concentration","downstream_event_id":1882,"downstream_event":"Disrupted meiotic initiation of fetal oogonia of the ovary"},{"relation":2829,"upstream_event_id":1882,"upstream_event":"Disrupted meiotic initiation of fetal oogonia of the ovary","downstream_event_id":1883,"downstream_event":"Reduced size of the ovarian follicle pool "},{"relation":2889,"upstream_event_id":1883,"upstream_event":"Reduced size of the ovarian follicle pool ","downstream_event_id":405,"downstream_event":"irregularities, ovarian cycle"},{"relation":2875,"upstream_event_id":405,"upstream_event":"irregularities, ovarian cycle","downstream_event_id":406,"downstream_event":"impaired, Fertility"}]}