{"id":394,"title":"SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)","short_name":"SARS-CoV-2 causes anosmia","created_at":"2021-04-25T11:05:39.000-04:00","updated_at":"2023-09-25T16:27:07.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1738,"event":"SARS-CoV-2 cell entry ","event_type":"KeyEvent"},{"event_id":1847,"event":"Increased SARS-CoV-2 production","event_type":"KeyEvent"},{"event_id":1870,"event":"Sustentacular cells, decrease ","event_type":"KeyEvent"},{"event_id":1871,"event":"olfactory sensory neurons, decrease ","event_type":"KeyEvent"},{"event_id":1872,"event":"Olfactory epithelium degeneration","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1873,"event":"impaired olfactory function (anosmia) ","event_type":"AdverseOutcome"}],"relationships":[{"relation":2643,"upstream_event_id":1739,"upstream_event":"Binding to ACE2","downstream_event_id":1738,"downstream_event":"SARS-CoV-2 cell entry "},{"relation":2648,"upstream_event_id":1870,"upstream_event":"Sustentacular cells, decrease ","downstream_event_id":1873,"downstream_event":"impaired olfactory function (anosmia) "},{"relation":2649,"upstream_event_id":1871,"upstream_event":"olfactory sensory neurons, decrease ","downstream_event_id":1873,"downstream_event":"impaired olfactory function (anosmia) "},{"relation":2911,"upstream_event_id":1738,"upstream_event":"SARS-CoV-2 cell entry ","downstream_event_id":1847,"downstream_event":"Increased SARS-CoV-2 production"},{"relation":2912,"upstream_event_id":1847,"upstream_event":"Increased SARS-CoV-2 production","downstream_event_id":1870,"downstream_event":"Sustentacular cells, decrease "},{"relation":2645,"upstream_event_id":1870,"upstream_event":"Sustentacular cells, decrease ","downstream_event_id":1871,"downstream_event":"olfactory sensory neurons, decrease "},{"relation":2646,"upstream_event_id":1871,"upstream_event":"olfactory sensory neurons, decrease ","downstream_event_id":1872,"downstream_event":"Olfactory epithelium degeneration"},{"relation":2647,"upstream_event_id":1872,"upstream_event":"Olfactory epithelium degeneration","downstream_event_id":1873,"downstream_event":"impaired olfactory function (anosmia) "}]}