{"id":392,"title":"Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation","short_name":" Dysregulated fibrinolysis/bradykinin leading to hyperinflammation","created_at":"2021-04-20T02:35:18.000-04:00","updated_at":"2023-09-25T16:27:06.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":624,"stressor_name":"Sars-CoV-2"},{"stressor_id":224,"stressor_name":"nanoparticles"},{"stressor_id":634,"stressor_name":"nanomaterials"},{"stressor_id":749,"stressor_name":"Titanium dioxide nanoparticles"},{"stressor_id":750,"stressor_name":"Iron nanoparticles"}],"aop_mies":[{"event_id":1866,"event":"Fibrinolysis, decreased","event_type":"MolecularInitiatingEvent"},{"event_id":1867,"event":"Bradykinin system, hyperactivated","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1496,"event":"Increased, secretion of proinflammatory mediators","event_type":"KeyEvent"},{"event_id":1497,"event":"Increased, recruitment of inflammatory cells","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1868,"event":"Hyperinflammation","event_type":"AdverseOutcome"}],"relationships":[{"relation":2633,"upstream_event_id":1866,"upstream_event":"Fibrinolysis, decreased","downstream_event_id":1867,"downstream_event":"Bradykinin system, hyperactivated"},{"relation":2638,"upstream_event_id":1866,"upstream_event":"Fibrinolysis, decreased","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":2637,"upstream_event_id":1867,"upstream_event":"Bradykinin system, hyperactivated","downstream_event_id":1866,"downstream_event":"Fibrinolysis, decreased"},{"relation":2634,"upstream_event_id":1867,"upstream_event":"Bradykinin system, hyperactivated","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":2639,"upstream_event_id":1867,"upstream_event":"Bradykinin system, hyperactivated","downstream_event_id":1868,"downstream_event":"Hyperinflammation"},{"relation":2635,"upstream_event_id":1496,"upstream_event":"Increased, secretion of proinflammatory mediators","downstream_event_id":1497,"downstream_event":"Increased, recruitment of inflammatory cells"},{"relation":2636,"upstream_event_id":1497,"upstream_event":"Increased, recruitment of inflammatory cells","downstream_event_id":1868,"downstream_event":"Hyperinflammation"}]}