{"id":382,"title":"Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis","short_name":"AT1R, lung fibrosis","created_at":"2021-03-30T12:00:28.000-04:00","updated_at":"2023-09-25T16:27:06.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1851,"event":"Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1115,"event":"Increased, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1172,"event":"Increase activation, Nuclear factor kappa B (NF-kB)","event_type":"KeyEvent"},{"event_id":1496,"event":"Increased, secretion of proinflammatory mediators","event_type":"KeyEvent"},{"event_id":68,"event":"Accumulation, Collagen","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1276,"event":"Lung fibrosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2572,"upstream_event_id":1851,"upstream_event":"Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)","downstream_event_id":1115,"downstream_event":"Increased, Reactive oxygen species"},{"relation":2573,"upstream_event_id":1115,"upstream_event":"Increased, Reactive oxygen species","downstream_event_id":1172,"downstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)"},{"relation":2574,"upstream_event_id":1172,"upstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":2575,"upstream_event_id":1496,"upstream_event":"Increased, secretion of proinflammatory mediators","downstream_event_id":68,"downstream_event":"Accumulation, Collagen"},{"relation":2576,"upstream_event_id":68,"upstream_event":"Accumulation, Collagen","downstream_event_id":1276,"downstream_event":"Lung fibrosis"}]}