{"id":379,"title":"Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation","short_name":"SARS-CoV2 to thrombosis and DIC","created_at":"2021-03-25T19:30:46.000-04:00","updated_at":"2023-09-25T16:27:06.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":633,"stressor_name":"Stressor:624 SARS-CoV-2"}],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1738,"event":"SARS-CoV-2 cell entry ","event_type":"KeyEvent"},{"event_id":1901,"event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","event_type":"KeyEvent"},{"event_id":1847,"event":"Increased SARS-CoV-2 production","event_type":"KeyEvent"},{"event_id":1869,"event":"Diminished protective oxidative stress response","event_type":"KeyEvent"},{"event_id":1845,"event":"Coagulation","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1846,"event":"Thrombosis and Disseminated Intravascular Coagulation","event_type":"AdverseOutcome"}],"relationships":[{"relation":3104,"upstream_event_id":1739,"upstream_event":"Binding to ACE2","downstream_event_id":1738,"downstream_event":"SARS-CoV-2 cell entry "},{"relation":3107,"upstream_event_id":1738,"upstream_event":"SARS-CoV-2 cell entry ","downstream_event_id":1901,"downstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2"},{"relation":3108,"upstream_event_id":1901,"upstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","downstream_event_id":1847,"downstream_event":"Increased SARS-CoV-2 production"},{"relation":2640,"upstream_event_id":1847,"upstream_event":"Increased SARS-CoV-2 production","downstream_event_id":1869,"downstream_event":"Diminished protective oxidative stress response"},{"relation":2641,"upstream_event_id":1869,"upstream_event":"Diminished protective oxidative stress response","downstream_event_id":1845,"downstream_event":"Coagulation"},{"relation":2642,"upstream_event_id":1845,"upstream_event":"Coagulation","downstream_event_id":1869,"downstream_event":"Diminished protective oxidative stress response"},{"relation":2526,"upstream_event_id":1845,"upstream_event":"Coagulation","downstream_event_id":1846,"downstream_event":"Thrombosis and Disseminated Intravascular Coagulation"}]}