{"id":377,"title":"Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)","short_name":"TLR9 activation leading to Multi Organ Failure and ARDS","created_at":"2021-03-19T09:45:21.000-04:00","updated_at":"2023-09-25T16:27:05.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":628,"stressor_name":"cell free mitochondrial DNA (mtDNA)"},{"stressor_id":629,"stressor_name":"unmethylated CpG motifs (DNA;RNA;ODN)"},{"stressor_id":526,"stressor_name":"SARS-CoV"},{"stressor_id":624,"stressor_name":"Sars-CoV-2"},{"stressor_id":631,"stressor_name":"Danger Associated Molecular Patters (DAMPs)"},{"stressor_id":632,"stressor_name":"Pathogen Associated Molecular Patterns (PAMPs)"}],"aop_mies":[{"event_id":1842,"event":"Prolonged TLR9 activation","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1897,"event":"increased MyD88 activation","event_type":"KeyEvent"},{"event_id":1895,"event":"NLRP3 inflammasome activity, increased","event_type":"KeyEvent"},{"event_id":1172,"event":"Increase activation, Nuclear factor kappa B (NF-kB)","event_type":"KeyEvent"},{"event_id":87,"event":"Release, Cytokine","event_type":"KeyEvent"},{"event_id":1493,"event":"Increased Pro-inflammatory mediators","event_type":"KeyEvent"},{"event_id":1497,"event":"Increased, recruitment of inflammatory cells","event_type":"KeyEvent"},{"event_id":1708,"event":"Th17 cell migration and inflammation induction","event_type":"KeyEvent"},{"event_id":1088,"event":"Increased, Oxidative Stress","event_type":"KeyEvent"},{"event_id":1392,"event":"Oxidative Stress ","event_type":"KeyEvent"},{"event_id":1869,"event":"Diminished protective oxidative stress response","event_type":"KeyEvent"},{"event_id":211,"event":"Propagation, Oxidative stress","event_type":"KeyEvent"},{"event_id":177,"event":"N/A, Mitochondrial dysfunction 1","event_type":"KeyEvent"},{"event_id":55,"event":"Cell injury/death","event_type":"KeyEvent"},{"event_id":1825,"event":"Increase, Cell death","event_type":"KeyEvent"},{"event_id":1809,"event":"Increase, Tissue/organ damage","event_type":"KeyEvent"},{"event_id":1898,"event":"increased release of danger/damage associated molecular patterns","event_type":"KeyEvent"},{"event_id":1848,"event":"Toll Like Receptor (TLR) Dysregulation","event_type":"KeyEvent"},{"event_id":1900,"event":"increased platelet surface TLR9 expression","event_type":"KeyEvent"},{"event_id":1899,"event":"formation of neutrophil extracellular traps (NETs)","event_type":"KeyEvent"},{"event_id":1857,"event":"Platelet-neutrophil interactions, Increased ","event_type":"KeyEvent"},{"event_id":1846,"event":"Thrombosis and Disseminated Intravascular Coagulation","event_type":"KeyEvent"},{"event_id":1496,"event":"Increased, secretion of proinflammatory mediators","event_type":"KeyEvent"},{"event_id":1868,"event":"Hyperinflammation","event_type":"KeyEvent"},{"event_id":902,"event":"Inflammation, Liver","event_type":"KeyEvent"},{"event_id":1844,"event":"systemic inflammatory response syndrome","event_type":"KeyEvent"},{"event_id":1748,"event":"Increase, the risk of acute respiratory failure","event_type":"KeyEvent"},{"event_id":1535,"event":"Heart failure ","event_type":"KeyEvent"},{"event_id":814,"event":"Occurrence, Kidney toxicity","event_type":"KeyEvent"},{"event_id":759,"event":"Increased, Kidney Failure","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1843,"event":"Multi Organ Failure involving Acute Respiratory Distress Syndrome","event_type":"AdverseOutcome"},{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":2755,"upstream_event_id":1842,"upstream_event":"Prolonged TLR9 activation","downstream_event_id":1897,"downstream_event":"increased MyD88 activation"},{"relation":2761,"upstream_event_id":1842,"upstream_event":"Prolonged TLR9 activation","downstream_event_id":1895,"downstream_event":"NLRP3 inflammasome activity, increased"},{"relation":2756,"upstream_event_id":1897,"upstream_event":"increased MyD88 activation","downstream_event_id":1172,"downstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)"},{"relation":2757,"upstream_event_id":1172,"upstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)","downstream_event_id":87,"downstream_event":"Release, Cytokine"},{"relation":2758,"upstream_event_id":1172,"upstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)","downstream_event_id":1493,"downstream_event":"Increased Pro-inflammatory mediators"},{"relation":2759,"upstream_event_id":1172,"upstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":2760,"upstream_event_id":87,"upstream_event":"Release, Cytokine","downstream_event_id":1497,"downstream_event":"Increased, recruitment of inflammatory cells"}]}