{"id":366,"title":"Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis ","short_name":"TH displacement from serum TTR leading to altered amphibian metamorphosis","created_at":"2020-12-09T14:43:30.000-05:00","updated_at":"2023-09-25T16:27:04.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":957,"event":"Binding, Transthyretin in serum","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1830,"event":"Displacement, Serum thyroxine (T4) from carrier protein","event_type":"KeyEvent"},{"event_id":959,"event":"Increased, Free serum thyroxine (T4)","event_type":"KeyEvent"},{"event_id":1158,"event":"Increased, Hepatic thyroid hormone uptake/transport","event_type":"KeyEvent"},{"event_id":961,"event":"Increased, Clearance of thyroxine from serum","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1101,"event":"Altered, Amphibian metamorphosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2455,"upstream_event_id":957,"upstream_event":"Binding, Transthyretin in serum","downstream_event_id":1830,"downstream_event":"Displacement, Serum thyroxine (T4) from carrier protein"},{"relation":2453,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1101,"downstream_event":"Altered, Amphibian metamorphosis"},{"relation":2456,"upstream_event_id":1830,"upstream_event":"Displacement, Serum thyroxine (T4) from carrier protein","downstream_event_id":959,"downstream_event":"Increased, Free serum thyroxine (T4)"},{"relation":2450,"upstream_event_id":959,"upstream_event":"Increased, Free serum thyroxine (T4)","downstream_event_id":1158,"downstream_event":"Increased, Hepatic thyroid hormone uptake/transport"},{"relation":2454,"upstream_event_id":1158,"upstream_event":"Increased, Hepatic thyroid hormone uptake/transport","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2822,"upstream_event_id":1158,"upstream_event":"Increased, Hepatic thyroid hormone uptake/transport","downstream_event_id":961,"downstream_event":"Increased, Clearance of thyroxine from serum"},{"relation":2823,"upstream_event_id":961,"upstream_event":"Increased, Clearance of thyroxine from serum","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"}]}