{"id":365,"title":"Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning","short_name":"TPOi photoreceptor patterning","created_at":"2020-12-09T07:47:23.000-05:00","updated_at":"2023-09-25T16:27:04.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":279,"event":"Thyroperoxidase, Inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":277,"event":"Thyroid hormone synthesis, Decreased","event_type":"KeyEvent"},{"event_id":281,"event":" Thyroxine (T4) in serum, Decreased","event_type":"KeyEvent"},{"event_id":1003,"event":"Decreased, Triiodothyronine (T3)","event_type":"KeyEvent"},{"event_id":1640,"event":"Altered, Photoreceptor patterning","event_type":"KeyEvent"},{"event_id":1643,"event":"Altered, Visual function","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2666,"upstream_event_id":279,"upstream_event":"Thyroperoxidase, Inhibition","downstream_event_id":277,"downstream_event":"Thyroid hormone synthesis, Decreased"},{"relation":2667,"upstream_event_id":277,"upstream_event":"Thyroid hormone synthesis, Decreased","downstream_event_id":281,"downstream_event":" Thyroxine (T4) in serum, Decreased"},{"relation":2668,"upstream_event_id":281,"upstream_event":" Thyroxine (T4) in serum, Decreased","downstream_event_id":1003,"downstream_event":"Decreased, Triiodothyronine (T3)"},{"relation":2669,"upstream_event_id":1003,"upstream_event":"Decreased, Triiodothyronine (T3)","downstream_event_id":1640,"downstream_event":"Altered, Photoreceptor patterning"},{"relation":3142,"upstream_event_id":1640,"upstream_event":"Altered, Photoreceptor patterning","downstream_event_id":1643,"downstream_event":"Altered, Visual function"},{"relation":3143,"upstream_event_id":1643,"upstream_event":"Altered, Visual function","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":2672,"upstream_event_id":351,"upstream_event":"Increased Mortality","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}