{"id":361,"title":"Sulfonylureareceptor binding leading to mortality","short_name":"SUR binding leading to mortality","created_at":"2020-10-22T16:15:52.000-04:00","updated_at":"2023-09-25T16:27:04.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[],"aop_mies":[{"event_id":1525,"event":"Increase, Sulfonylurea receptor binding","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1527,"event":"Increase, Cell membrane depolarization","event_type":"KeyEvent"},{"event_id":1526,"event":"Increase, Opening of voltage-dependent calcium channel","event_type":"KeyEvent"},{"event_id":1523,"event":"Decrease, Cuticular chitin content","event_type":"KeyEvent"},{"event_id":1524,"event":"Increase, Premature molting","event_type":"KeyEvent"}],"aop_aos":[{"event_id":350,"event":"Increase, Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":2286,"upstream_event_id":1525,"upstream_event":"Increase, Sulfonylurea receptor binding","downstream_event_id":1527,"downstream_event":"Increase, Cell membrane depolarization"},{"relation":2287,"upstream_event_id":1527,"upstream_event":"Increase, Cell membrane depolarization","downstream_event_id":1526,"downstream_event":"Increase, Opening of voltage-dependent calcium channel"},{"relation":2288,"upstream_event_id":1526,"upstream_event":"Increase, Opening of voltage-dependent calcium channel","downstream_event_id":1523,"downstream_event":"Decrease, Cuticular chitin content"},{"relation":2289,"upstream_event_id":1523,"upstream_event":"Decrease, Cuticular chitin content","downstream_event_id":1524,"downstream_event":"Increase, Premature molting"},{"relation":2290,"upstream_event_id":1524,"upstream_event":"Increase, Premature molting","downstream_event_id":350,"downstream_event":"Increase, Mortality"}]}