{"id":360,"title":"Chitin synthase 1 inhibition leading to mortality","short_name":"CHS-1 inhibition leading to mortality","created_at":"2020-10-22T16:11:08.000-04:00","updated_at":"2023-09-25T16:27:04.000-04:00","corresponding_author":{"id":17712,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":369,"stressor_name":"Polyoxin B"},{"stressor_id":593,"stressor_name":"Polyoxin D"},{"stressor_id":368,"stressor_name":"Nikkomycins"},{"stressor_id":595,"stressor_name":"Captan"},{"stressor_id":594,"stressor_name":"Captafol"},{"stressor_id":596,"stressor_name":"Folpet"}],"aop_mies":[{"event_id":1522,"event":"Inhibition, Chitin synthase 1","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1523,"event":"Decrease, Cuticular chitin content","event_type":"KeyEvent"},{"event_id":1524,"event":"Increase, Premature molting","event_type":"KeyEvent"}],"aop_aos":[{"event_id":350,"event":"Increase, Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":2283,"upstream_event_id":1522,"upstream_event":"Inhibition, Chitin synthase 1","downstream_event_id":1523,"downstream_event":"Decrease, Cuticular chitin content"},{"relation":2284,"upstream_event_id":1523,"upstream_event":"Decrease, Cuticular chitin content","downstream_event_id":1524,"downstream_event":"Increase, Premature molting"},{"relation":2285,"upstream_event_id":1524,"upstream_event":"Increase, Premature molting","downstream_event_id":350,"downstream_event":"Increase, Mortality"}]}