{"id":349,"title":"Inhibition of 11β-hydroxylase leading to decresed population trajectory ","short_name":"11β-hydroxylase inhibition,  infertility in fish ","created_at":"2020-07-12T10:16:17.000-04:00","updated_at":"2023-09-25T16:27:04.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":574,"stressor_name":"Metyrapone"},{"stressor_id":575,"stressor_name":"Lysodren, Mitotan, Mitotane"},{"stressor_id":576,"stressor_name":"Etomidate"},{"stressor_id":282,"stressor_name":"Ketoconazole"},{"stressor_id":577,"stressor_name":"Osilodrostat(LCI699)"}],"aop_mies":[{"event_id":1796,"event":"11β-hydroxylase inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1835,"event":"Cortisol and 11β-(OH) testosterone decreased","event_type":"KeyEvent"},{"event_id":1756,"event":"Decreased,  plasma 11-ketotestosterone level","event_type":"KeyEvent"},{"event_id":1836,"event":"Decreased plasma Cortisol level","event_type":"KeyEvent"},{"event_id":1798,"event":"Decreased spermatogenesis ","event_type":"KeyEvent"},{"event_id":1837,"event":"decreased oocyte maturation","event_type":"KeyEvent"},{"event_id":406,"event":"impaired, Fertility","event_type":"KeyEvent"}],"aop_aos":[{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2501,"upstream_event_id":1796,"upstream_event":"11β-hydroxylase inhibition","downstream_event_id":1835,"downstream_event":"Cortisol and 11β-(OH) testosterone decreased"},{"relation":2531,"upstream_event_id":1835,"upstream_event":"Cortisol and 11β-(OH) testosterone decreased","downstream_event_id":1756,"downstream_event":"Decreased,  plasma 11-ketotestosterone level"},{"relation":2532,"upstream_event_id":1835,"upstream_event":"Cortisol and 11β-(OH) testosterone decreased","downstream_event_id":1836,"downstream_event":"Decreased plasma Cortisol level"},{"relation":2533,"upstream_event_id":1756,"upstream_event":"Decreased,  plasma 11-ketotestosterone level","downstream_event_id":1798,"downstream_event":"Decreased spermatogenesis "},{"relation":2534,"upstream_event_id":1836,"upstream_event":"Decreased plasma Cortisol level","downstream_event_id":1837,"downstream_event":"decreased oocyte maturation"},{"relation":2535,"upstream_event_id":1798,"upstream_event":"Decreased spermatogenesis ","downstream_event_id":406,"downstream_event":"impaired, Fertility"},{"relation":2536,"upstream_event_id":1837,"upstream_event":"decreased oocyte maturation","downstream_event_id":406,"downstream_event":"impaired, Fertility"},{"relation":2537,"upstream_event_id":406,"upstream_event":"impaired, Fertility","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}