{"id":348,"title":"Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory ","short_name":"11βHSD inhibition, decreased population trajectory","created_at":"2020-07-03T12:44:29.000-04:00","updated_at":"2023-09-25T16:27:03.000-04:00","corresponding_author":{"id":17716,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-11-28T16:27:24.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":572,"stressor_name":"N-(5-Hydroxytricyclo[3.3.1.13,7]dec-2-yl)-α,α-dimethyl-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazineacetamide"},{"stressor_id":545,"stressor_name":"Carbenoxolone"},{"stressor_id":578,"stressor_name":"Glycyrrhizin"},{"stressor_id":579,"stressor_name":"PF915275"}],"aop_mies":[{"event_id":1799,"event":"Inhibition of 11β-HSD ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1756,"event":"Decreased,  plasma 11-ketotestosterone level","event_type":"KeyEvent"},{"event_id":1758,"event":"Impaired, Spermatogenesis","event_type":"KeyEvent"},{"event_id":406,"event":"impaired, Fertility","event_type":"KeyEvent"}],"aop_aos":[{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2253,"upstream_event_id":1799,"upstream_event":"Inhibition of 11β-HSD ","downstream_event_id":1756,"downstream_event":"Decreased,  plasma 11-ketotestosterone level"},{"relation":2254,"upstream_event_id":1756,"upstream_event":"Decreased,  plasma 11-ketotestosterone level","downstream_event_id":1758,"downstream_event":"Impaired, Spermatogenesis"},{"relation":2529,"upstream_event_id":1758,"upstream_event":"Impaired, Spermatogenesis","downstream_event_id":406,"downstream_event":"impaired, Fertility"},{"relation":2530,"upstream_event_id":406,"upstream_event":"impaired, Fertility","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}