{"id":343,"title":"S-adenosylmethionine depletion leading to population decline (2)","short_name":"SAM depletion leading to population decline (2)","created_at":"2020-05-08T07:10:57.000-04:00","updated_at":"2023-09-25T16:27:03.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":370,"stressor_name":"Teflubenzuron"},{"stressor_id":371,"stressor_name":"Diflubenzuron"},{"stressor_id":373,"stressor_name":"Glibenclamide"}],"aop_mies":[{"event_id":1525,"event":"Increase, Sulfonylurea receptor binding","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1527,"event":"Increase, Cell membrane depolarization","event_type":"KeyEvent"},{"event_id":1526,"event":"Increase, Opening of voltage-dependent calcium channel","event_type":"KeyEvent"},{"event_id":1523,"event":"Decrease, Cuticular chitin content","event_type":"KeyEvent"},{"event_id":1524,"event":"Increase, Premature molting","event_type":"KeyEvent"}],"aop_aos":[{"event_id":350,"event":"Increase, Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":2179,"upstream_event_id":1525,"upstream_event":"Increase, Sulfonylurea receptor binding","downstream_event_id":1527,"downstream_event":"Increase, Cell membrane depolarization"},{"relation":2180,"upstream_event_id":1527,"upstream_event":"Increase, Cell membrane depolarization","downstream_event_id":1526,"downstream_event":"Increase, Opening of voltage-dependent calcium channel"},{"relation":2181,"upstream_event_id":1526,"upstream_event":"Increase, Opening of voltage-dependent calcium channel","downstream_event_id":1523,"downstream_event":"Decrease, Cuticular chitin content"},{"relation":2182,"upstream_event_id":1523,"upstream_event":"Decrease, Cuticular chitin content","downstream_event_id":1524,"downstream_event":"Increase, Premature molting"},{"relation":2183,"upstream_event_id":1524,"upstream_event":"Increase, Premature molting","downstream_event_id":350,"downstream_event":"Increase, Mortality"}]}