{"id":339,"title":"DNA methyltransferase inhibition leading to population decline (4)","short_name":" DNMT inhibtion leading to population decline (4)","created_at":"2020-04-26T06:09:30.000-04:00","updated_at":"2023-09-25T16:27:03.000-04:00","corresponding_author":{"id":17711,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":442,"stressor_name":"5-Azacytidine"}],"aop_mies":[{"event_id":1619,"event":"Increase, DNA methyltransferase inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1766,"event":"Increase, DNA double-strand break","event_type":"KeyEvent"},{"event_id":1774,"event":"Increase, Caspase transcription","event_type":"KeyEvent"},{"event_id":1776,"event":"Increase, Ovarian somatic cell apoptosis","event_type":"KeyEvent"},{"event_id":1777,"event":"Increase, Ovarian follicle breakdown","event_type":"KeyEvent"},{"event_id":1366,"event":"Decrease, Oogenesis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":328,"event":"Decrease, Fecundity","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[]}