{"id":337,"title":"DNA methyltransferase inhibition leading to population decline (2)","short_name":" DNMT inhibtion leading to population decline (2)","created_at":"2020-04-26T06:08:36.000-04:00","updated_at":"2023-09-25T16:27:02.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":442,"stressor_name":"5-Azacytidine"}],"aop_mies":[{"event_id":1619,"event":"Increase, DNA methyltransferase inhibition","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1773,"event":"Decrease, Global DNA methylation","event_type":"KeyEvent"},{"event_id":1774,"event":"Increase, Caspase transcription","event_type":"KeyEvent"},{"event_id":1776,"event":"Increase, Ovarian somatic cell apoptosis","event_type":"KeyEvent"},{"event_id":1777,"event":"Increase, Ovarian follicle breakdown","event_type":"KeyEvent"},{"event_id":1366,"event":"Decrease, Oogenesis","event_type":"KeyEvent"}],"aop_aos":[{"event_id":328,"event":"Decrease, Fecundity","event_type":"AdverseOutcome"},{"event_id":360,"event":"Decrease, Population growth rate","event_type":"AdverseOutcome"}],"relationships":[{"relation":2151,"upstream_event_id":1619,"upstream_event":"Increase, DNA methyltransferase inhibition","downstream_event_id":1773,"downstream_event":"Decrease, Global DNA methylation"},{"relation":2152,"upstream_event_id":1773,"upstream_event":"Decrease, Global DNA methylation","downstream_event_id":1774,"downstream_event":"Increase, Caspase transcription"},{"relation":2153,"upstream_event_id":1774,"upstream_event":"Increase, Caspase transcription","downstream_event_id":1776,"downstream_event":"Increase, Ovarian somatic cell apoptosis"},{"relation":2154,"upstream_event_id":1776,"upstream_event":"Increase, Ovarian somatic cell apoptosis","downstream_event_id":1777,"downstream_event":"Increase, Ovarian follicle breakdown"},{"relation":2155,"upstream_event_id":1777,"upstream_event":"Increase, Ovarian follicle breakdown","downstream_event_id":1366,"downstream_event":"Decrease, Oogenesis"},{"relation":2156,"upstream_event_id":1366,"upstream_event":"Decrease, Oogenesis","downstream_event_id":328,"downstream_event":"Decrease, Fecundity"},{"relation":2157,"upstream_event_id":328,"upstream_event":"Decrease, Fecundity","downstream_event_id":360,"downstream_event":"Decrease, Population growth rate"}]}