330-54-1 XMTQQYYKAHVGBJ-UHFFFAOYSA-N XMTQQYYKAHVGBJ-UHFFFAOYSA-N Diuron Urea, N'-(3,4-dichlorophenyl)-N,N-dimethyl- (3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYL UREA 1-(3,4-Dichlorophenyl)-3,3-dimethylurea 1,1-DIMETHYL-3-(3,4-DICHLOROPHENYL)UREA 3-(3,4-DICHLOROPHENYL)-1,1-DIMETHYL UREA Dironet Dironzol Diuron Nortox DP Hardener 95 Dyhard UR 200 Herbatox HRT Dinron Karmex D Karmex Diuron Herbicide Karmex DW Lucenit N'-(3,4-Dichlorophenyl)-N,N-dimethyl urea N'-(3,4-Dichlorophenyl)-N,N-dimethylurea N-(3,4-Dichlorophenyl)-N',N'-dimethylurea N,N-Dimethyl-N'-(3,4-dichlorophenyl)urea N'-3,4-DICHLOROPHENYL N,N-DIMETHYLUREA NSC 8950 Preventol A 6 Telvar Diuron Weed Killer Urea, 3-(3,4-dichlorophenyl)-1,1-dimethyl- 3-(3,4-Dichlorophenyl)-1,1-dimethylurea DTXSID0020446 GO:0005739 GO mitochondrion CL:0000731 CL urothelial cell GO:0008283 GO cell proliferation D006965 MESH hyperplasia 7 WIKI functional change 1 WIKI increased Diuron 2018-05-24T15:29:12 2018-05-24T15:29:12 DCA 2022-06-03T08:10:48 2022-06-03T08:10:48 DCPMU 2022-06-03T08:11:10 2022-06-03T08:11:10 10116 NCBI rat Mitochondrial impairment Molecular CL:0000255 CL eukaryotic cell AOPWiki 2017-02-07T13:21:11 2017-09-16T10:17:43 cell injury Cellular AOPWiki 2020-04-21T18:09:26 2020-04-21T18:09:26 Increase, Regenerative cell proliferation (urothelial cells) Cellular CL:0000731 CL urothelial cell AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:21 Increase, Hyperplasia (urothelial) Cellular CL:0000731 CL urothelial cell AOPWiki 2016-11-29T18:41:27 2017-09-16T10:16:21 carcinogenicity Organ AOPWiki 2020-04-21T18:14:57 2020-04-21T19:38:14 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4313186588> AOPWiki 2020-04-21T18:42:07 2020-04-21T18:42:07 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4313353b18> AOPWiki 2020-04-21T18:42:39 2020-04-21T18:42:39 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b4313361b28> AOPWiki 2016-11-29T18:41:35 2016-12-03T16:38:00 #<Reference::ActiveRecord_Associations_CollectionProxy:0x00007b43133a3190> AOPWiki 2020-04-21T18:43:23 2020-04-21T18:43:23 Chemical cytotoxicity leading to urothelial carcinogenesis Arthur Author <p>^a,bNathalia P Souza, ^a,bThania RR Lima, ^b,cLilian C Pereira, ^a,bJoao Lauro V de Camargo</p> <p>^aBotucatu Medical School, UNESP &ndash; Sao Paulo State University, Botucatu Campus, Department of Pathology. ^bCenter for Evaluation of Environmental Impact on Human Health (TOXICAM), Botucatu, SP, Brazil. ^cSchool of Agricultural Sciences, UNESP - Sao Paulo State University, Botucatu Campus, Department of Bioprocesses and Biotechnology, Botucatu, SP, Brazil.</p> BY-SA 2.0 <p>We are proposing an AOP framework for urothelial cytotoxicity followed by regenerative hyperplasia and the development of benign and malignant proliferative lesions after long-term chemical exposure. In addition, we suggest direct mitochondrial dysfunction process as one of the possible Molecular Initiating Event (MIE) for this AOP. Our lab has a long experience with urothelial toxicity resulting from exposure to the herbicide diuron. Currently, we are adopting <em>in vitro</em> approaches using human bladder cells (1T1) exposed to diuron and its metabolites to confirm the mitochondrial damage and to identify the intracellular pathways that are compromised after exposure. We suggest that the mitochondrial impairment in urothelial cells leads to urothelial injury/death followed by regenerative cell proliferation and hyperplasia, culminating in urothelial tumors.</p> adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified adjacent Not Specified Not Specified Not Specified Male Not Specified Not Specified Not Specified Not Specified <p style="text-align:justify">Fava RM,&nbsp;Ferragut Cardoso AP,&nbsp;da Rocha MS,&nbsp;Nascimento E Pontes MG,&nbsp;de&nbsp;Camargo&nbsp;JL,&nbsp;de Oliveira ML. Evaluation of early changes induced by&nbsp;diuron&nbsp;in the rat urinary bladder using different processing methods for scanning electron microscopy.&nbsp;Toxicology.&nbsp;3;333:100-6.&nbsp;2015.</p> <p style="text-align:justify">Ihlaseh-Catalano SM, Bailey KA, Cardoso AP, Ren H, Fry RC, de Camargo JL, Wolf DC. Dose and temporal effects on gene expression profiles of urothelial cells from rats exposed to diuron. Toxicology. 5;325:21-30. 2014</p> <p style="text-align:justify">Da Rocha MS, Arnold LL, De Oliveira ML, Catalano SM, Cardoso AP, Pontes MG, Ferrucio B, Dodmane PR, Cohen SM, De Camargo JL. Diuron-induced rat urinary bladder carcinogenesis: mode of action and human relevance evaluations using the International Programme on Chemical Safety framework. Crit Rev Toxicol. 44(5):393-406. 2014.</p> <p style="text-align:justify">Da Rocha MS, Arnold LL, Dodmane PR, Pennington KL, Qiu F, De Camargo JL, Cohen SM. Diuron metabolites and urothelial cytotoxicity: in vivo, in vitro and molecular approaches. Toxicology. 15;314(2-3):238-46. 2013.</p> <p style="text-align:justify">Cardoso AP, Ihlaseh Catalano SM, da Rocha MS, Nascimento E Pontes MG, de Camargo JL, de Oliveira ML. Dose-response of diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] in the urothelial mucosa of Wistar rats. Toxicology. 4;312:1-5. 2013.</p> <p style="text-align:justify">Da Rocha MS, Arnold LL, Pennington KL, Muirhead D, Dodmane PR, Anwar MM, Battalora M, De Camargo JL, Cohen SM. Diuron-induced rat bladder epithelial cytotoxicity. Toxicol Sci. 130(2):281-8. 2012.</p> <p style="text-align:justify">Ihlaseh SM, Bailey KA, Hester SD, Jones C, Ren H, Cardoso AP, Oliveira ML, Wolf DC, de Camargo JL. Transcriptional profile of diuron-induced toxicity on the urinary bladder of male Wistar rats to inform mode of action. Toxicol Sci.122(2):330-8. 2011.</p> <p style="text-align:justify">da Rocha MS, Nascimento MG, Cardoso AP, de Lima PL, Zelandi EA, de Camargo JL, de Oliveira ML. Cytotoxicity and regenerative proliferation as the mode of action for diuron-induced urothelial carcinogenesis in the rat. Toxicol Sci. 113(1):37-44. 2010.</p> <p style="text-align:justify">Nascimento MG, de Oliveira ML, Lima AS, de Camargo JL. Effects of Diuron [3-(3,4-dichlorophenyl)-1,1-dimethylurea] on the urinary bladder of male Wistar rats. Toxicology. 5;224(1-2):66-73. 2006.</p> <p style="text-align:justify">Thania Rios Rossi Lima, Estela de Oliveira Lima, Jeany Delafiori, Rodrigo Ramos Catharino, Jo&atilde;o Lauro Viana de Camargo &amp; L&iacute;lian Cristina Pereira&nbsp;(2022)&nbsp;Molecular signatures associated with diuron exposure on rat&nbsp;urothelial mitochondria,&nbsp;Toxicology Mechanisms and Methods,&nbsp;DOI:&nbsp;<a href="https://doi.org/10.1080/15376516.2022.2062271">10.1080/15376516.2022.2062271</a>.</p> AOPWiki 2020-04-21T16:26:59 2023-09-25T16:27:02