{"id":335,"title":"AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment ","short_name":"Chemical cytotoxicity leading to urothelial carcinogenesis","created_at":"2020-04-21T16:26:59.000-04:00","updated_at":"2023-09-25T16:27:02.000-04:00","corresponding_author":{"id":17713,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-12-20T10:05:07.000-05:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":367,"stressor_name":"Diuron"},{"stressor_id":741,"stressor_name":"DCA"},{"stressor_id":742,"stressor_name":"DCPMU"}],"aop_mies":[{"event_id":1261,"event":"Mitochondrial impairment","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1762,"event":"Urothelial cell injury/death","event_type":"KeyEvent"},{"event_id":795,"event":"Increase, Regenerative cell proliferation (urothelial cells)","event_type":"KeyEvent"},{"event_id":796,"event":"Increase, Hyperplasia (urothelial)","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1763,"event":"Urothelial Tumor","event_type":"AdverseOutcome"}],"relationships":[{"relation":2120,"upstream_event_id":1261,"upstream_event":"Mitochondrial impairment","downstream_event_id":1762,"downstream_event":"Urothelial cell injury/death"},{"relation":2121,"upstream_event_id":1762,"upstream_event":"Urothelial cell injury/death","downstream_event_id":795,"downstream_event":"Increase, Regenerative cell proliferation (urothelial cells)"},{"relation":2122,"upstream_event_id":795,"upstream_event":"Increase, Regenerative cell proliferation (urothelial cells)","downstream_event_id":796,"downstream_event":"Increase, Hyperplasia (urothelial)"},{"relation":2123,"upstream_event_id":796,"upstream_event":"Increase, Hyperplasia (urothelial)","downstream_event_id":1763,"downstream_event":"Urothelial Tumor"}]}