{"id":320,"title":"Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality","short_name":"SARS-CoV-2 leads to acute respiratory distress","created_at":"2020-03-01T10:04:20.000-05:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17710,"created_at":"2023-09-11T18:10:58.000-04:00","updated_at":"2023-09-11T18:10:58.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":526,"stressor_name":"SARS-CoV"},{"stressor_id":620,"stressor_name":"HCoV-NL63"},{"stressor_id":624,"stressor_name":"Sars-CoV-2"}],"aop_mies":[{"event_id":1739,"event":"Binding to ACE2","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1738,"event":"SARS-CoV-2 cell entry ","event_type":"KeyEvent"},{"event_id":1901,"event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","event_type":"KeyEvent"},{"event_id":1847,"event":"Increased SARS-CoV-2 production","event_type":"KeyEvent"},{"event_id":1848,"event":"Toll Like Receptor (TLR) Dysregulation","event_type":"KeyEvent"},{"event_id":1496,"event":"Increased, secretion of proinflammatory mediators","event_type":"KeyEvent"},{"event_id":1750,"event":"Increased inflammatory immune responses","event_type":"KeyEvent"},{"event_id":1748,"event":"Increase, the risk of acute respiratory failure","event_type":"KeyEvent"}],"aop_aos":[{"event_id":351,"event":"Increased Mortality","event_type":"AdverseOutcome"}],"relationships":[{"relation":2490,"upstream_event_id":1739,"upstream_event":"Binding to ACE2","downstream_event_id":1738,"downstream_event":"SARS-CoV-2 cell entry "},{"relation":2632,"upstream_event_id":1847,"upstream_event":"Increased SARS-CoV-2 production","downstream_event_id":1848,"downstream_event":"Toll Like Receptor (TLR) Dysregulation"},{"relation":2552,"upstream_event_id":1848,"upstream_event":"Toll Like Receptor (TLR) Dysregulation","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":2093,"upstream_event_id":1496,"upstream_event":"Increased, secretion of proinflammatory mediators","downstream_event_id":1750,"downstream_event":"Increased inflammatory immune responses"},{"relation":2094,"upstream_event_id":1750,"upstream_event":"Increased inflammatory immune responses","downstream_event_id":1748,"downstream_event":"Increase, the risk of acute respiratory failure"},{"relation":2216,"upstream_event_id":1748,"upstream_event":"Increase, the risk of acute respiratory failure","downstream_event_id":351,"downstream_event":"Increased Mortality"},{"relation":3105,"upstream_event_id":1738,"upstream_event":"SARS-CoV-2 cell entry ","downstream_event_id":1901,"downstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2"},{"relation":3106,"upstream_event_id":1901,"upstream_event":"Interferon-I antiviral response, antagonized by SARS-CoV-2","downstream_event_id":1847,"downstream_event":"Increased SARS-CoV-2 production"}]}