{"id":319,"title":"Binding to ACE2 leading to lung fibrosis","short_name":"Binding to ACE2 leads to lung fibrosis","created_at":"2020-03-01T08:07:54.000-05:00","updated_at":"2023-09-25T16:27:01.000-04:00","corresponding_author":{"id":17717,"created_at":"2023-09-11T18:10:59.000-04:00","updated_at":"2023-09-12T12:20:02.000-04:00","subscribed":true,"novice":null},"aop_stressors":[{"stressor_id":528,"stressor_name":"PM 2.5"},{"stressor_id":550,"stressor_name":"Streptozocin"},{"stressor_id":551,"stressor_name":"Losartan"},{"stressor_id":621,"stressor_name":"DX600"},{"stressor_id":622,"stressor_name":"cationic polyamidoamine dendrimer (nanoparticle)"}],"aop_mies":[{"event_id":1740,"event":"Induced dysregulation of ACE2 ","event_type":"MolecularInitiatingEvent"}],"aop_kes":[{"event_id":1854,"event":"Dysregulation, ACE2 expression and activity","event_type":"KeyEvent"},{"event_id":1752,"event":"Increased Angiotensin II ","event_type":"KeyEvent"},{"event_id":1851,"event":"Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)","event_type":"KeyEvent"},{"event_id":1115,"event":"Increased, Reactive oxygen species","event_type":"KeyEvent"},{"event_id":1172,"event":"Increase activation, Nuclear factor kappa B (NF-kB)","event_type":"KeyEvent"},{"event_id":68,"event":"Accumulation, Collagen","event_type":"KeyEvent"},{"event_id":1496,"event":"Increased, secretion of proinflammatory mediators","event_type":"KeyEvent"}],"aop_aos":[{"event_id":1276,"event":"Lung fibrosis","event_type":"AdverseOutcome"}],"relationships":[{"relation":2219,"upstream_event_id":1740,"upstream_event":"Induced dysregulation of ACE2 ","downstream_event_id":1752,"downstream_event":"Increased Angiotensin II "},{"relation":3006,"upstream_event_id":1752,"upstream_event":"Increased Angiotensin II ","downstream_event_id":1851,"downstream_event":"Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)"},{"relation":3007,"upstream_event_id":1851,"upstream_event":"Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)","downstream_event_id":1115,"downstream_event":"Increased, Reactive oxygen species"},{"relation":3010,"upstream_event_id":1115,"upstream_event":"Increased, Reactive oxygen species","downstream_event_id":1172,"downstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)"},{"relation":3011,"upstream_event_id":1172,"upstream_event":"Increase activation, Nuclear factor kappa B (NF-kB)","downstream_event_id":1496,"downstream_event":"Increased, secretion of proinflammatory mediators"},{"relation":3012,"upstream_event_id":1496,"upstream_event":"Increased, secretion of proinflammatory mediators","downstream_event_id":68,"downstream_event":"Accumulation, Collagen"},{"relation":3009,"upstream_event_id":68,"upstream_event":"Accumulation, Collagen","downstream_event_id":1276,"downstream_event":"Lung fibrosis"}]}